1Department of Tumor Intelligent Rehabilitation Center Hefei Cancer Hospital Chinese Academy of Sciences Hefei 230088 Anhui
China
2Department of Nursing Hefei Cancer Hospital Chinese Academy of Sciences Hefei 230088 Anhui China
3 Hefei Institute of
Physical Sciences Chinese Academy of Sciences Hefei 230031 Anhui China
4Breast Cancer Center Hefei Cancer Hospital Chinese
Academy of Sciences Hefei 230088 Anhui China
5 Department of Anesthesiology Zhejiang Provincial People's Hospital Hangzhou
310000 Zhejiang China
Abstract：Objective To explore the symptoms and symptom cluster composition during chemotherapy in breast cancer patients
and to provide a basis for symptom management during chemotherapy in breast cancer patients. Method A total of 210 breast cancer
patients admitted to Hefei Cancer Hospital Chinese Academy of Sciences from May 2023 to August 2024 were selected and basic
information questionnaire and Chinese version of Memory Symptom Assessment Scale were used to conduct questionnaire surveys in the
first cycle of chemotherapy T1
the second cycle of chemotherapy T2
the third cycle of chemotherapy T3
and the last cycle of
chemotherapy T4
respectively. Questionnaire symptom clusters were extracted using exploratory factor analysis. Result Initially
210 breast cancer patients met the inclusion criteria. At the T1
T2
T3
T4
time points 210 205 199 and 192 breast cancer patients
participated in the follow-up respectively. The number of symptoms at each time node from T1
to T4 was 9 6 14 11 7 16 12 8
18 and 11 6 16 respectively. The number of symptoms with an incidence rate of greater than 20% at each time node from T1 to
T4 was 15 20 20 and 16 respectively. Three common factors were extracted from T1
including gastrointestinal symptom cluster
emotional and psychological symptom cluster and menopausal symptom cluster. Five common factors were extracted from T2
to T3
including gastrointestinal symptom cluster emotional and psychological symptom cluster neurological symptom cluster menopausal
symptom cluster and self - image disorder symptom cluster. Four common factors were extracted at T4
including gastrointestinal
symptom cluster emotional and psychological symptom cluster neurological symptom cluster and menopausal symptom cluster.Conclusion Breast cancer patients receiving adjuvant chemotherapy experience multiple symptoms and different symptom clusters
during different cycles of chemotherapy. Clinical staff should pay attention to the symptom clusters of breast cancer patients during
chemotherapy and take appropriate measures to actively intervene to alleviate multiple symptoms thereby reducing the impact of
symptom clusters on patients.
1姚婉晴,1卢 薇,2陈旦旦,2张晚秋,3杨立状,3丁增辉,4王 盈,5刘金涛. 乳腺癌患者辅助化疗期间症状群轨迹的纵向研究[J]. 肿瘤代谢与营养电子杂志, 2025, 12(2): 208-214.
1Yao Wanqing,1Lu Wei,2Chen Dandan,2Zhang Wanqiu,3Yang Lizhuang,3Ding Zenghui,4Wang Ying,5Liu Jintao. A longitudinal study of symptom cluster trajectories during adjuvant chemotherapy in breast cancer patients. Electron J Metab Nutr Cancer, 2025, 12(2): 208-214.
