Effects of prognostic nutrition index guided fractional nutrition therapy on immune function nutritional status and
complications in patients with colorectal cancer
Liu Daoqin, Zhao Qing, Wang Dan, Shi Sailei, Wang Fang
Department of Oncology Jiangsu Provincial People's Hospital The First Affiliated Hospital of Nanjing Medical University Nanjing
210029 Jiangsu China
Abstract：Objective To investigate the effects of graded nutrition therapy guided by prognostic nutrition index PNI on immune
function nutritional status and complications in patients with colorectal cancer. Method A total of 155 patients with colorectal cancer
who were diagnosed and treated in Jiangsu Provincial People 's Hospital from November 2023 to August 2024 were selected as the
research subjects and divided into the observation group treated with graded nutritional therapy under the guidance of PNI n = 78 and
the control group treated with conventional nutritional intervention n = 77 according to the random number table method. The time of
the first postoperative exhaust the time of eating the time of getting out of bed and the hospital stay were compared between the two
groups. Observe the levels of PNI at admission T0
1 day before surgery T1
7 days after surgery T2
and 30 days after surgery
T3
as well as the levels of serum CD4
+
T cells CD4
+
/ CD8
+
T cells CD8
+
T cells albumin hemoglobin prealbumin at T0
and T3
and the complications. The correlation between PNI and complications was analyzed by Spearman method. Result The time of first
exhaust after surgery the time of first eating after surgery the time of first getting out of bed after surgery and the hospital stay in the
observation group were all shorter than those in the control group and the incidence of complications was lower than that in the control
group P<0. 05 . The serum albumin hemoglobin and prealbumin of the two groups 30 days after the operation increased significantly
compared with those at admission P < 0. 05 . The serum albumin hemoglobin and prealbumin in the observation group 30 days after
the operation were all higher than those in the control group P<0. 05 . The CD4
+
T cells CD4
+
/ CD8
+
T cells and CD8
+
T cells in the
observation group at time point T3 were all higher than those in the control group P<0. 05 . The PNI of the observation group at time
points T1
T2
and T3 was all higher than that of the control group P<0. 05 . Conclusion PNI guided fractional nutrition therapy is
beneficial to improve nutritional status and immune function promote intestinal function recovery and reduce the incidence of complications in patients with colorectal cancer which is of great significance to improve the quality of life of patients.
刘道勤,赵 青,王 丹,施赛磊,王 方. 预后营养指数指导下分级营养疗法对结直肠癌患者免疫功能、营养状况及并发症的影响[J]. 肿瘤代谢与营养电子杂志, 2025, 12(4): 441-447.
Liu Daoqin, Zhao Qing, Wang Dan, Shi Sailei, Wang Fang. Effects of prognostic nutrition index guided fractional nutrition therapy on immune function nutritional status and
complications in patients with colorectal cancer. Electron J Metab Nutr Cancer, 2025, 12(4): 441-447.
