Clinical application of probiotics combined with low-GI high-quality protein diet in regulating muscle and fat metabolism in
obese patients
1Lin Bing, 1Yang Jing, 1 2Zhu Cuifeng
1Department of Clinical Nutrition Shenzhen Hospital of Southern Medical University Shenzhen 518000 Guangdong China
2
Shenzhen
Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Hospital of Southern Medical University Shenzhen 518000
Guangdong China
Abstract：Objective To explore the effects and analysis of probiotics combined with low glycemic index GI and high-quality
protein diet intervention on muscle mass fat mass and grip strength in obese patients. Method A total of 110 obese patients who
attended the Department of Clinical Nutrition Shenzhen Hospital of Southern Medical University from July to December 2024 were
selected and randomly divided into an intervention group n = 55 and a control group n = 55 using the random number table
method. All obese patients received an individualized low GI and high-quality protein diet which includes an energy intake of 20
kcal / kg·d energy ratio of 30% for protein 40% for carbohydrates and 30% for fat and dietary fiber intake of 14 g / d. The
intervention group was given an additional probiotic preparation besides the dietary intervention for 8 weeks. The changes of body
weight and body composition after the intervention were compared. All gastrointestinal adverse reactions were recorded. Result There
was no significantly difference in body weight body mass index muscle mass and grip strength between the two groups at the baseline
P > 0. 05 . After the intervention the body weight of both groups decreased P<0. 05 . The weight loss of the intervention group was
-6. 14±4. 00 kg which was higher than that of the control group -4. 43±3. 19 kg P<0. 05 . Moreover the muscle loss in the
intervention group was less than that in control group - 1. 35± 1. 48 kg vs - 2. 31± 1. 74 kg P < 0. 05 while the fat loss was
greater. The analysis of both male and female subgroups showed a consistent muscle protection effect. Especially after the intervention
the grip strength of females was significantly greater than that of control group P = 0. 032 . Probiotics can reduce the incidence of
constipation during the intervention P = 0. 031 and there are no other serious adverse events. Conclusion The intervention of
probiotics combined with a low-GI and high-quality protein diet can effectively reduce the weight body fat mass of obese patients and
may protect the muscles and strength during the weight loss process through the gut-muscle axis.
