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| Prospective randomized controlled study of the effects of neoadjuvant chemoradiotherapy combined with immunonutrition on
rectal tumor infiltration and regulatory T lymphocytes |
| Xia Chang, Jin Tao, Huang Kaiping, Zhai Shaohong, Hu Huan, Wu Xuan |
| Department of Oncology Liyuan Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan 430000 Hubei China |
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Abstract Objective To explore the effects of immunonutrition on tumor-infiltrating T-lymphocytes and regulatory T-cells in
rectal tumor patients receiving neoadjuvant chemoradiotherapy. Method Prospective selected 120 rectal tumor patients admitted to the
Oncology Department of Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from
September 2020 to June 2023 divided into 2 groups according to the random number table method. The control group of 60 patients
were treated with routine nutritional support in the observation group 60 patients received immunonutritional support cancer cell
proliferation and apoptosis PI AI AI / PI gastrointestinal hormone levels VIP MTL GAS tumor infiltration and regulatory T
lymphocyte numbers Th3 TGF-β CD3
+
CD8
+
and nutritional status PA Hb ALB at 30d after treatment. Result Cancer cell
proliferation and apoptosis gastrointestinal hormone levels nutritional status tumor infiltration and regulated T lymphocytes were
better than before treatment P <0. 05 . Comparison of the post-treatment effects between the two groups observation group PI AI
AI / PI VIP MTL GAS Th3 TGF-β CD3
+
CD8
+
. the improvement was better than that in the control group The difference
was statistically significant P<0. 05 . Meanwhile the treated PA Hb ALB were higher than the control group with statistically
significant differences P<0. 05 . Conclusion Immunonutritional support for rectal tumor patients receiving neoadjuvant radiotherapy
and chemotherapy can promote cancer cell apoptosis inhibit cancer cell differentiation and proliferation improve nutritional status and
gastrointestinal function and improve body immunity which is the preferred treatment mode for rectal tumor.
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| Cite this article: |
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Xia Chang,Jin Tao,Huang Kaiping, et al. Prospective randomized controlled study of the effects of neoadjuvant chemoradiotherapy combined with immunonutrition on
rectal tumor infiltration and regulatory T lymphocytes[J]. Electron J Metab Nutr Cancer, 2025, 12(1): 45-51.
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| URL: |
| http://www.ejmnc.com//EN/ OR http://www.ejmnc.com//EN/Y2025/V12/I1/45 |
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