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| Clinical supplementation of β-hydroxy-β-methylbutyrate and its mechanisms |
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Abstract Objective To review recent clinical literatures on the effectiveness of HMB supplementation in pathological
conditions. Methods Utilizing electronic online database search using the keyword HMB, then screened, compared and summarized
the results of HMB supplementation. Results β-hydroxy-β-methylbutyrate is a metabolite of the essential amino acid leucine. Plenty
of researches show that HMB may have the effect in preventing muscle wasting and increasing muscle mass, and has been widely
used in sports and body building. Many diseases, such as severe trauma, cancer, AIDS, the elderly muscle atrophy may lead to muscle
wasting. Therefore, HMB is also used in clinical treatment for muscle wasting in the past few years. Conclusions Although there are
discrepancies among the results of different studies, HMB supplementation has been shown its increase effect on lean body mass in
the most of literatures. Consequently, HMB supplementation attenuates muscle wasting and reduces the risk of poor prognosis. It may
due to the complex metabolism of HMB.
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| [1] |
WANG Chao-yun， DU Cheng， GUAN Xin， DU Xiao-wei， XU Zhu-xuan， ZHENG Zhen-dong. Advances in drug therapy for cancer cachexia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 382-385. |
| [2] |
1，2ZHU Ming-xing， 1WU Chang-peng， 3YIN Liang-yu，1LU Zong-liang， 1LI Na，1LIU Jie， 1GUO Jing， 1XU Hong-xia. L-carnitine improves skeletal muscle cell atrophy of cancer cachexia by regulating lipid metabolism[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 320-325. |
| [3] |
1CAI Jun-xiang, 2LOU Hui-ling . Sarcopenia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(1): 135-143. |
| [4] |
GUAN Chun-yan, NIU Hui-yan. Research progress in cancer cachexia-induced regulation of skeletal muscle oxidative metabolism[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 342-347. |
| [5] |
1LIU Jin-peng 2LU Xiao-Lan. Biomarkers of carcinemia and cancer treatment related complications[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(3): 247-250. |
| [6] |
WU Hai-tao, WANG Chang, LI Wei. Diagnosis and treatment of tumor cachexia[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(3): 231-235. |
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2015, Vol. 2 
