The predictive value of the pre - treatment hemoglobin albumin lymphocyte and platelet score for the prognosis of
radiotherapy in esophageal squamous cell carcinoma
1
School of Medicine University of Electronic Science and Technology of China Chengdu 610041 Sichuan China
2
Second Department of
Thoracic Radiotherapy Sichuan Cancer Hospital Chengdu 610041 Sichuan China
3 Department of Clinical Medicine Southwest Medical
University Luzhou 646000 Sichuan China
4Department of Clinical Medicine Chengdu Medical College Chengdu 610041 Sichuan China
Abstract：Objective To investigate the predictive value of the pre-treatment hemoglobin-albumin-lymphocyte-platelet HALP
score for overall survival in patients with esophageal squamous cell carcinoma ESCC undergoing radical radiotherapy and to construct
a nomogram model to evaluate its predictive performance. Method A retrospective analysis was conducted on 246 patients with stage
Ⅲ/ Ⅳ ESCC admitted to Sichuan Cancer Hospital from March 2012 to November 2018. The pre-treatment HALP score was calculated
and the optimal cutoff value was determined using X - tile. The correlation between HALP and clinicopathological features was
analyzed. Prognostic factors were assessed using the Kaplan-Meier method and Cox regression models. A nomogram was constructed
and its predictive performance was validated. Result The low HALP group was significantly associated with more advanced T stage N
stage and clinical stage P < 0. 05 . The high HALP group showed significantly better 1- 3- and 5-year overall survival rates
compared to the low HALP group 74. 7% vs 54. 0% 46. 6% vs 25. 6% 36. 9% vs 19. 8% P < 0. 001 . Multivariate Cox
proportional hazards regression model analysis identified drinking history T stage and HALP as independent prognostic factors for
overall survival P < 0. 05 . The nomogram model for predicting overall survival had a C - index of 0. 687 demonstrating good
predictive performance and calibration plots indicated high predictive accuracy. Conclusion A low pre-treatment HALP score is an
independent poor prognostic factor for overall survival in ESCC patients undergoing radical radiotherapy. The HALP-based nomogram
model may provide a reference for individualized prognostic assessment.
1张 雪,1肖 苓,2郑秀梅,1刘雨欣,3牟春晓,4倪 爽,2吕家华. 治疗前血红蛋白 -白蛋白 -淋巴细胞 -血小板评分对
食管鳞状细胞癌放疗预后的预测价值[J]. 肿瘤代谢与营养电子杂志, 2025, 12(6): 730-738.
1Zhang Xue,1 Xiao Ling,2 Zheng Xiumei,1Liu Yuxin,3Mu Chunxiao,4 Ni Shuang,2Lyu Jiahua. The predictive value of the pre - treatment hemoglobin albumin lymphocyte and platelet score for the prognosis of
radiotherapy in esophageal squamous cell carcinoma. Electron J Metab Nutr Cancer, 2025, 12(6): 730-738.
