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| Association between nutritional status and functional limitation in elderly patients with colorectal cancer under an endoscopic
pathway |
| Guo Hong, Wang Kaili, Zhang Ying, Zhou Han |
| Department of Gastroscopy and Colonoscopy Affiliated Hospital of North China University of Science and Technology Tangshan 063016
Hebei China |
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Abstract Objective To investigate the relationship between nutritional status and functional limitation under the endoscopic care
pathway and to clarify the impact of hemoglobin levels and protein intake on functional impairment in elderly colorectal cancer
patients providing evidence for peri - endoscopic functional maintenance. Method Data from the NHANES 2005 - 2018 were
analyzed. Patients aged ≥60 years with colorectal cancer were included. Hemoglobin levels protein intake and functional limitation
were assessed. Restricted cubic spline RCS was used to explore non -linear associations. Logistic and linear regression analyses
evaluated the relationship between nutritional exposures and functional limitation risk and severity. Subgroup analyses explored the
effects of gender BMI and diabetes. Result A total of 319 patients were included with a functional limitation prevalence of 60. 8%.
Functional limitation risk increased significantly when hemoglobin was below 130 g / L or protein intake was below 60 g / d P < 0. 001 .
Each 10 g / L increase in hemoglobin reduced functional limitation risk by 34% each 1 g increase in protein intake reduced risk by
2%. Patients with anemia and low protein intake had the highest risk OR = 19. 68 95% CI = 4. 20-92. 17 P < 0. 001 . Subgroup
analyses showed stronger associations in males lower BMI and non-diabetic patients. Hemoglobin and protein intake were negatively
associated with functional limitation scores. Conclusion Hemoglobin levels and protein intake are protective factors against functional
limitation in elderly colorectal cancer patients undergoing endoscopic care. Optimizing nutritional status should be integrated into the
endoscopic nursing pathway to enhance perioperative functional reserves.
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