目的 探究医用组织胶联合微波消融治疗周围型肺癌的疗效评估。 方法 采用前瞻性研究设计,选取 2021 年 1 月至 2023 年 12 月巴音郭楞蒙古自治州人民医院收治的符合纳入排除标准治疗 1 个月的周围型肺癌患者 105 例,通过随机数字表 法分为观察组(n = 53)与对照组(n = 52),对照组采用微波消融治疗,观察组在此基础上联用医用组织胶。 对比两组患者干预 1 个月后的临床疗效;随访 3 年,统计两组生存率与复发率;Cox 比例风险回归模型分析预后影响因素;对比两组生活质量与并 发症发生情况。 结果 治疗 1 个月后,观察组的完全消融率、疾病控制率(DCR)、客观缓解率(ORR) 显著高于对照组(P< 0. 05);随访 3 年,观察组的总生存(OS)、无进展生存(PFS)高于对照组,局部复发率低于对照组(P<0. 05);Cox 比例风险回归 模型显示,联合治疗、肿瘤直径≤3 cm 是 OS 的独立保护因素。 分层分析显示,联合治疗对肿瘤直径≤3 cm 的患者治疗效果更 显著(P<0. 05)。 治疗 3 个月后,观察组生活质量评分高于对照组(P<0. 05)。 观察组总并发症发生率低于对照组,且无重度 并发症发生。 结论 医用组织胶联合微波消融对周围型肺癌介入治疗比单独微波消融治疗具有更好的疗效,可降低患者的复 发率,提高患者的 3 年生存率。

Objective Exploring the efficacy evaluation of medical tissue glue combined with microwave ablation in the treatment of peripheral lung cancer. Method A prospective study design was adopted. A total of 105 patients with peripheral lung cancer who met the inclusion criteria and were admitted to Bayingolin Mongolian Autonomous Prefecture People 's Hospital from January 2021 to December 2023 were selected. They were divided into an observation group n = 53 and a control group n = 52 using a random number table method. The control group was treated with microwave ablation while the observation group was treated with microwave ablation combined with medical tissue glue. The clinical efficacy of the two groups was compared after 3 years of follow-up the survival rate and recurrence rate of the two groups were statistically analyzed the Cox proportional hazards regression model was used to analyze the prognostic factors and the quality of life and incidence of complications of the two groups were compared. Result After 1 month of treatment the complete ablation rate disease control rate DCR and objective response rate ORR in the observation group were significantly higher than those in the control group P <0. 05 . After 3 years of follow-up the overall survival OS and progression-free survival PFS in the observation group were higher than those in the control group while the local recurrence rate was lower than that in the control group P <0. 05 . Cox regression analysis showed that combined treatment and tumor diameter ≤3 cm were independent protective factors for OS. Stratified analysis showed that the combined therapy had a more significant therapeutic effect on patients with tumor diameter ≤3 cm P <0. 05 . After 3 months of treatment the quality of life score in the observation group was higher than that in the control group P <0. 05 . The total incidence of complications in the observation group was lower than that in the control group and no severe complications occurred. Conclusion The combination of medical tissue glue and microwave ablation in the interventional treatment of peripheral lung cancer has better efficacy than microwave ablation alone. It can reduce the recurrence rate of patients improve their 3-year survival rate.