Objective To retrieve evaluate and summarize the best evidence of hospice nutritional therapy for cancer patients at home and abroad and to provide scientific basis for clinical hospice medical staff to choose the appropriate nutritional therapy strategy. Method According to the top-down principle of the evidence-based resource 6S model computer decision support systems guideline websites association official websites and databases were systematically searched for the relevant evidence on hospice nutritional therapy for cancer patients including clinical decision making guidelines evidence summaries systematic reviews best practice expert consensus meta-analysis randomized controlled trials. The search period was from the establishment of the databases to June 30 2024. Two researchers conducted quality evaluation and data extraction on the literature. Result A total of 18 articles were included including 9 guidelines 1 systematic review 3 clinical decisions 3 expert consensus and 2 randomized controlled trials. After extracting and integrating the evidence included in the literature a total of 28 best pieces of evidence were finally summarized from six aspects such as establishing a multidisciplinary nutritional therapy team nutrition risk screening and assessment nutritional therapy decision support comprehensive nutrition intervention complication management individualized nursing. Conclusion This study offers evidence-based guidance for health care professionals in selecting nutritional treatment strategies providing meaningful insights for enhancing the quality of hospice nutrition care for cancer patients.