Objective To investigate the relationship between dietary branched-chain amino acid intake and glycolipid indices in patients with colorectal cancer in order to provide a theoretical basis for ameliorating glycolipid metabolism disorders in patients. Method Colorectal cancer patients were selected according to the inclusion and exclusion criteria from the databases of the Multicentre Study on Nutritional Status and Clinical Outcomes of Common Malignant Tumors in China INSCOC study and the Current Status of Dietary Intake and Its Influencing Factors in Patients with Common Malignant Tumors. Dietary questionnaires general information laboratory indicators and other data were collected and analyzed using multiple linear regression and multifactorial Logistic regression. Result The results of the multiple linear regression analysis revealed that the average daily intake of branched-chain amino acids BCAA in the diet could significantly and negatively predict the levels of fasting blood glucose FPG total cholesterol TC and high - density lipoprotein cholesterol HDL - C . Abnormal total cholesterol and abnormal abnormal high density lipoprotein cholesterol HDL-C . Multivariate Logistic analysis showed that moderate and high intakes of various branched-chain amino acids in the diet were protective factors for the occurrence of FPG abnormalities. After adjusting for confounding the risk of abnormal TC was 2. 07 times higher in the moderate daily leucine intake group than in the low intake group and the protective factor was the moderate and high daily dietary branched-chain amino acid intake group. Triglyceride TG abnormalities were a protective factor in the medium and high daily intake groups of leucine and valine. The higher daily intake of isoleucine was the protective factor. Average daily intake of branched - chain amino acids was a protective factor for HDL - C abnormalities. The risk of abnormal low density lipoprotein cholesterol LDL-C was 3. 60 times higher in the moderate daily intake group than in the low intake group. Conclusion The results of this study suggest that a higher intake of branched - chain amino acids is more likely to be a protective factor for abnormalities of glycolipid metabolism in colorectal cancer patients with the moderate - intake group of AVG - Leu being a risk factor for TC abnormalities and the moderate-intake group of AVG-BCAA being a risk factor for LDL-C abnormalities.