Assessment of body composition and sarcopenia in the prognosis of patients with chronic obstructive pulmonary disease

Gu Jiawei, Zhu Xiangyang, Ji Hongyan, Xu Yan

Electronic Journal of Metabolism and Nutrition of Cancer ›› 2025, Vol. 12 ›› Issue (2) : 215-220.

PDF(1587 KB)
PDF(1587 KB)
Electronic Journal of Metabolism and Nutrition of Cancer ›› 2025, Vol. 12 ›› Issue (2) : 215-220.

Assessment of body composition and sarcopenia in the prognosis of patients with chronic obstructive pulmonary disease

  • Gu Jiawei, Zhu Xiangyang, Ji Hongyan, Xu Yan
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Abstract

Objective To evaluate the prognostic value of body composition and sarcopenia in patients with chronic obstructive pulmonary disease COPD . Method A total of 185 COPD patients admitted to Nantong Cancer Hospital from June 2021 to June 2022 were included. The patients were followed up for 1 year and their survival was recorded. All patients' clinical information baseline data were measured and recorded at admission. General information included age sex BMI hypertension and diabetes. Body composition indicators include waist circumference phase angle midarm circumference calf circumference. Result A total of 185 patients observed 16 died representing a mortality rate of 8. 6%. According to whether the patients died or not the results showed that The age and incidence of sarcopenia in death group were significantly higher than those in survival group while the phase angle was significantly lower in death group compared to the survival group with statistically significant differences P<0. 05 . Cox proportional model results showed that age reduction was significantly associated with a lower risk of death in COPD patients HR= 0. 832 95%CI = 0. 706-0. 982 P= 0. 030 . Sarcopenia was significantly associated with an increased risk of death in COPD patients HR = 3. 377 95% CI = 1. 126- 10. 1330 P = 0. 030 . Decreased phase Angle was significantly associated with increased risk of death in COPD patients HR= 2. 746 95% CI = 1. 165-6. 472 P= 0. 021 . ROC curve results showed that the AUC of age predicting the prognosis of COPD was 0. 814 the maximum Youden index was 0. 546 the corresponding sensitivity was 88. 2% and the specificity was 66. 4%. Sarcopenia predicted the outcome of COPD with an AUC of 0. 780 a maximum Youden index of 0. 417 a corresponding sensitivity of 64. 7% and a specificity of 77. 0%. The phase angle predicted the prognosis of COPD with an AUC of 0. 850 a maximum Youden index of 0. 612 a corresponding sensitivity of 88. 2% and a specificity of 73. 0%. Conclusion Both decreased phase angle and sarcopenia were significantly associated with an increased risk of death in COPD patients. Decreased phase angle and sarcopenia have high prognostic value in COPD patients. However due to the relatively small sample size in this study the model's stability is suboptimal.

Key words

Body composition / Calf circumference / Sarcopenia / Chronic obstructive pulmonary disease / Prognosis / Age / Phase angle / Risk of death

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Gu Jiawei, Zhu Xiangyang, Ji Hongyan, Xu Yan. Assessment of body composition and sarcopenia in the prognosis of patients with chronic obstructive pulmonary disease[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2025, 12(2): 215-220
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