With the advancement of comprehensive treatment modalities for malignant neoplasm the survival duration of affected patients has progressively increased thereby amplifying the demand for home-based rehabilitation. Home-based exercise is recognized as a critical non-pharmacological intervention due to its cost-effectiveness accessibility and numerous health benefits playing a pivotal role in the recovery of patients with malignant neoplasms. Recent evidence suggests that structured home-based exercise can effectively reduce the risk of cardiovascular complications prevent oxalate-induced muscle atrophy enhance immune function and significantly improve patients' quality of life through mechanisms such as the regulation of inflammatory factors and the enhancement of muscle metabolism. Nevertheless current data indicates that patients with malignant neoplasms frequently exhibit low adherence to prescribed home exercise regimens. Misconceptions regarding exercise along with symptoms such as cancer-related fatigue and pain represent significant barriers that contribute to their reduced compliance with home - based exercise programs. Addressing these challenges requires a multifaceted approach including overcoming cognitive barriers by precision - tailored exercise prescriptions integrating intelligent assistive technologies and consolidating multidisciplinary resources to establish a safe evidence -based and sustainable home-based exercise rehabilitation framework. Such a model holds significant potential to improve clinical outcomes and enhance patients' quality of life. This article seeks to examine four critical dimensions of home exercise for patients with malignant neoplasms risk assessment types of home exercise adherence to home exercise regimens and follow-up. The findings aim to serve as a reference for the enhanced promotion of home exercise among this patient population.