Objective To explore the predictive value of preoperative serum levels of angiopoietin Ang - 2 and galactin - 3 Gal-3 in the prognosis evaluation of non-small cell lung cancer NSCLC patients after thoracoscopic. Method A total of 92 NSCLC patients who underwent thoracoscopic from January 2019 to January 2021 in our hospital were regarded as the study subjects. According to the follow-up results they were separated into a recurrent group n = 34 and a non recurrent group n = 58 . Serum Ang-2 and Gal-3 levels were detected using ELISA method. The correlation between Ang-2 and Gal-3 levels in the serum of NSCLC patients was analyzed using Pearson 's method. Logistic regression was applied to analyze the relevant factors affecting the prognosis of NSCLC patients. ROC curve was applied to evaluate the predictive value of serum Ang - 2 and Gal - 3 levels for the prognosis of NSCLC patients. Result Compared with the non recurrent group the serum Ang- 2 and Gal- 3 level in the recurrent group increased P< 0. 05 . Pearson correlation analysis results showed a obvious positive correlation between serum Ang-2 and Gal-3 levels in NSCLC patients r = 0. 503 P< 0. 001 . There were no significant differences in smoking history presence of nerve invasion presence of vascular invasion pathological type age intraoperative blood loss or operation time between the recurrence group and the non - recurrence group P>0. 05 . However there was a obvious difference P<0. 05 in TNM staging and differentiation degree. TNM staging differentiation degree serum Ang - 2 and Gal - 3 levels were all influencing factors for postoperative recurrence in NSCLC patients P<0. 05 . The combined prediction of serum Ang-2 and Gal-3 for the prognosis of NSCLC patients had an AUC of 0. 965 sensitivity of 88. 24% and specificity of 98. 28% which was better than Ang-2 and Gal-3 alone prediction Z combination - Ang-2 = 3. 221 P= 0. 001 Z combination - Gal-3 = 2. 063 P= 0. 039 . Conclusion In NSCLC patients serum Ang-2 and Gal-3 levels are elevated and can serve as auxiliary serum markers for evaluating the prognosis of thoracoscopic in NSCLC patients.