Objective To explore the status of demoralization in lung cancer patients and analyze the influencing factors of different profile categories. Method A total of 150 lung cancer patients diagnosed and treated in the First Affiliated Hospital of Anhui Medical University from April 2023 to September 2024 were continuously included as the research subjects by the convenience sampling method. They were surveyed by using the basic information questionnaire the disorientation scale and the family care index questionnaire. The latent profile analysis of the characteristics of demoralization syndrome in lung cancer patients was conducted and the influencing factors of the latent profile analysis of demoralization syndrome were explored through single - factor combined with Logistic regression analysis. Result 150 valid questionnaires were collected. The average age was 61. 09±9. 42 years including 112 males 74. 67% and 38 females 25. 33% . The demoralization of lung cancer patients was divided into three latent profile analysis categories high desensitization group medium desensitization group and low desensitization group. The average probability of lung cancer patients belonging to each latent profile analysis was 0. 964 0. 950 0. 964 respectively. Univariate analysis showed that family income level place of residence presence of comorbidities family function and body mass index had statistically significant differences in the groups of lung cancer patients with demoralization P < 0. 05 . Conclusion There is heterogeneity of demoralization in lung cancer patients and it is affected by family income level place of residence comorbidities family function and body mass index. Clinical staff should identify the characteristics of different categories of patients and actively adopt countermeasures for patients with high desensitization of lung cancer so as to reduce their desensitization status as much as possible and reduce the occurrence of chain reactions such as psychological pain and life-weariness caused by desensitization.