目的： 探讨在肠内营养中添加海洋胶原低聚肽对食管癌术后患者血浆蛋白及相关并发症的影响。方法  按照研究纳入和排除标准，将120例食管癌患者，随机分为试验组和对照组，每组60例。两组患者均于术后24小时内进行早期肠内营养治疗，其中试验组患者肠内营养液中添加了海洋胶原低聚肽6g，3次/d，以替代部分蛋白质供给；对照组患者肠内营养液中未添加海洋胶原低聚肽，两组患者肠内营养液均按照相同能量和蛋白质供给标准进行配制。观察两组患者术后第7天血浆白蛋白、前白蛋白水平，肺部感染、吻合口瘘发生率，以及体重丢失程度和术后住院时间。结果  两组患者术后第7天血浆白蛋白及前白蛋白水平较术前均明显下降（P＜0.05），试验组患者术后第7天血浆白蛋白及前白蛋白水平显著高于对照组，差异均具有统计学意义（P＜0.05）；试验组患者的术后肺部感染发生率低于对照组，差异具有统计学意义（P＜0.05），吻合口瘘发生率差异无统计学意义（P＞0.05）；两组患者出院时体重较术前均有所下降，但两组患者体重丢失程度相比差异无统计学意义（P＞0.05）；对照组患者术后住院时间显著长于试验组，差异具有统计学意义（P＜0.05）。结论  肠内营养中使用海洋胶原低聚肽可以有效维持食管癌术后患者血浆蛋白水平，降低食管癌术后肺部感染的发生率，缩短术后住院时间。

Objective：To observe the effect of enteral nutrition with marine collagen oligopeptide on plasma protein and complications in postoperative patients with esophageal cancer. MethodsAccording to the inclusive and exclusive standard, 120 patients with esophageal cancer were randomized into study group and control group, with 60 cases in each group. Patients were given early enteral nutritional support within 24 hours after the operation. The study group patients were given with enteral nutrient solution with the marine collagen oligopeptide 6g, Tid, to replace part of the protein supply, and the control group patients were
given with enteral nutrient solution without the marine collagen oligopeptide. Both groups were prepared with the same energy and protein supply standards. The effect was evaluated with the plasma albumin and prealbumin on the 7th postoperative day, incidence of pulmonary infection and anastomotic fistula, body weight loss and length of hospital stay. ResultsIn both groups, on the 7th postoperative day, the plasma albumin and prealbumin levels were lower than the preoperative (both P<0.05); the plasma albumin and prealbumin of the study group were higher than the control group on the 7th postoperative day (both P<0.05), the study group had lower incidence of pulmonary infection than the control group (P<0.05), no significant differences about the incidence of anastomotic fistula were observed between two groups (P>0.05), the weight of the patients in both groups decreased compared with that before operation (both P<0.05), the body mass loss were no significant differences between two groups (P>0.05), the study group had shorter length of hospital stay than the control group (P<0.05). ConclusionsThe enteral nutrient solution with the marine collagen oligopeptide were effective in maintaining the plasma protein, reducing the incidence of pulmonary infection and shortening the time of hospitalization for the patients after esophagectomy.