肌肉减少症是一种渐进性、全身性的综合征，属于增龄性疾病，主要表现为骨骼肌体积减少，肌力下降和机能减退。 肌肉减少症不仅是机体运动系统衰老的一个表现，也是全身病理生理状态的反应。骨骼肌不仅是人体的运动系统，同时也 是机体不可或缺的物质代谢器官，参与机体的分泌和代谢过程，如葡萄糖、糖原、脂质代谢及分泌多种细胞因子等。代谢 综合征是以肥胖、糖代谢异常或糖尿病、高血压和血脂异常为主，多种代谢性疾病并存的一组临床症候群。老人由于体力 活动水平下降和机体代谢能力下降，发生肌肉减少症的几率大大增加，进而导致代谢性疾病如高血脂、高血压、糖尿病等 老年疾病频发。两者都与人体老化、代谢能力的下降密切相关，均属于年龄相关性疾病，由于代谢综合征并不是指一种疾病， 因此研究代谢综合征与肌肉减少症之间的关系，本质是研究相关疾病与肌肉减少症之间的关系，本文将从两种疾病共同的 病理基础、代谢异常角度对两者之间的关系进行综述。

Sarcopenia is a progressive, systemic syndrome, which is an age-related disease, mainly manifests in the reduction of skeletal muscle mass, decreased muscle strength and function. Skeletal muscle is not only the movement system of human body, but also the body metabolism organ, which involves in the secretion and metabolism of the body, such as glucose, glycogen and lipid metabolism, secreting a variety of cytokines, etc. Metabolic syndrome is a group of clinical syndromes with multiple metabolic disease are mainly characterized by obesity, abnormal glucose metabolism or diabetes, hypertension and dyslipidemia. Due to physical activity levels falling and metabolism ability decreasing, the chance of muscle reduce disease has greatly increased in elder people, leading to metabolic diseases such as high cholesterol, high blood pressure, diabetes and other diseases of the elderly. The two diseases are both closely related to the declining ability of the human body aging, metabolism, and belong to age-related diseases. Because the metabolic syndrome is not a single disease, the research of the relationship between metabolic syndrome and reduce muscle diseases is truly studying the relationship between the related disease and reduce muscle disease. This article will interpret the relationship between the two diseases from both the common pathological basis and metabolic abnormality aspects.