COPD是老年人群中一种高发的慢性呼吸系统疾病，肌少症是COPD的并发症之一。近年来，有许多文献报道了老年COPD患者合并肌少症的现象，现以“肌少症”和“COPD”为主要关键词在CNKI，VIPI，万方和Pubmed进行检索发现：在老年人群中，COPD合并肌少症的患病率不低。老年COPD患者合并肌少症的危险因素包括：高龄、低BMI、患COPD病程长、吸烟。COPD合并肌少症的病理生理机制较复杂，COPD患者发生肌少症的机制包括肌肉合成代谢减少、分解代谢增加。炎症因子、生长因子和激素是主要的促成因素。临床特征包括：身体活动受限、步态缓慢、耐力差、整个机体处于衰弱状态。药物干预策略尚处于研究阶段，其他干预策略包括：戒烟、合理运动、加强营养。合并肌少症的老年COPD患者，生活质量降低，住院率和死亡风险增加，预后不良。因此关注老年COPD合并肌少症对防治患者早期失能有着非常重要的意义。本文就老年COPD患者合并肌少症的流行病学、危险因素、病理生理机制、临床特征和诊断、干预与预后各方面进行综述。

Abstract: As a chronic respiratory disease, chronic obstructive pulmonary disease occupies a high incidence in the elderly, while sarcopenia is one of the complications in COPD. For the past few years, many researches have reported cases that many elderly people attacked COPD have sarcopenia. We find that there is a high prevalence of sarcopenia among the elderly people when we set “sarcopenia” and “COPD&r; as keywords to search in CNKI, VIPI, Wang fang and pubmed. The risk factors in elderly patients of COPD with sarcopenia include: advanced-age, low-BMI, long-course, smoking. The pathophysiological mechanism of elderly COPD with sarcopenia is complicated, including the anabolism of muscle decreases and the catabolism of muscle increases, and the inflammatory factor, growth factor and hormone are the mainly reasons. Clinical features include: limited physical activity, slow gait, poor endurance at the same time the entire body is in a weak state. Clinical features include: limited physical activity, slow gait, poor endurance and the entire body in a weak state. Drug intervention strategies are still in the research stage, and other intervention strategies include: smoking cessation, reasonable exercise, strengthen nutrition. Eldery COPD patients with sarcopenia have reduced quality of life, increased hospitalization and mortality risk, and have a poor prognosis. Therefore, to prevent elderly's disability in early stage, it is significant to pay attention to eldery COPD with sarcopenia. This article reviews the epidemiology, risk factors, pathophysiological mechanisms, clinical features, diagnosis, intervention and prognosis of elderly COPD with sarcopenia.