Objective To observe the effects of industrial three-chamber bag “Clinomel” intravenous nutrition on improving the nutritional immunological indexes and shortening the length of postoperative hospital stay in patients after colorectal cancer radical surgery. Methods From January to August 2017, patients with radical resection of rectal cancer in the gastrointestinal surgery affiliated to the Affiliated Cancer Hospital of Chongqing University were selected. According to the exclusion criteria, 80 patients were selected as the objects of the study. There were 41 cases in the Clinomel group and 39 in the control group. The differences in average age, weight, and body mass index between the two groups had no statistical significance (P>0.05), and the materials had good comparability. The changes of nutritional immunological indexes in the two groups were analyzed and the length of postoperative hospital stay was compared between the two groups. Results There were no significant differences between the two groups of albumin、prealbumin and globulin both pre-operation and the first day after operation (P>0.05); but the differences of albumin, prealbumin and globulin in 7 days after operation were statistically significant (P<0.05); the length of postoperative hospital stay of the Clinomel group was shorter than the control group, the difference was statistically significant (P<0.05). Conclusions Reasonable application of “Clinomel” for parenteral nutritional support therapy was beneficial to improve the nutritional status after radical operation of colorectal cancer, shorten postoperative hospital stay and improve the quality of life of patients.