Objective  Compared with the effects of Dexmedetomidine on the induction of anaesthesia using Marsh and Schnider models of propofol Target-controlled Infusion. Methods  60 patients with colorectal cancer scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy under general anesthesia were randomly divided into 2 groups: Marsh group (group M, n=30) and Schnider group (group S, n=30). All the patients received 0.8 µg/kg loading dose of dexmedetomidine, followed by TCI anaesthesia with remifentanil at 2 ng/mL. After the effect-site concentration of remifentanil reached 2 ng/mL, propofol TCI induction was started. Anaesthesia induction commenced in the Marsh group at a target plasma concentration of 2 µg/mL, whereas it started in the Schnider group at a target effect-site concentration of 2 µg/mL. If induction was delayed after 3 min, the target concentration was gradually increased to 0.5 µg/mL every 30 sec until successful induction. The Ct at successful induction, Ce at successful induction, induction time, and haemodynamic parameters were recorded. Results  The requirement of Ct for successful induction by Schnider model was significantly lower than that of Marsh model (3.43±0.22 VS 4.06±0.29μg/ml; P=0.05). Compared with Marsh model, the induction time of Schnider model was shorter (128.3±5.31 vs 160.7±3.30; P=0.01), and there was no significant change in hemodynamic parameters after successful induction. Conclusions  In the inter-group comparison, dexmedetomidine reduced the Ct concentration required for induction of Schnider model and shortened the induction time.