Analysis of expression and its clinical significance of UBE2T in lung cancer based on GEO database

LI Wei; GUO Zi-xing; LI Yong-hong; LIU Xiao-ping; HUANG Jing-yu; HU Wei-dong; LI Sheng

doi:10.16689/j.cnki.cn11-9349/r.2019.02.017

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2019, Vol. 6 ›› Issue (2) : 242-245. DOI: 10.16689/j.cnki.cn11-9349/r.2019.02.017

Analysis of expression and its clinical significance of UBE2T in lung cancer based on GEO database

1LI Wei， 2GUO Zi-xing， 1LI Yong-hong， 2LIU Xiao-ping， 2HUANG Jing-yu， 2HU Wei-dong， 3，4LI Sheng

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Abstract

Objective To investigate the expression of Ubiquitin-conjugating enzyme E2T(UBE2T) in lung cancer in the NCBI Gene Expression Omnibus (GEO) database and its relationship with clinicopathological characteristics and prognosis of lung cancer. Methods GEO datasets were collected and expression profile of UBE2T and clinicopathological information of lung cancer tissues were downloaded. The relationship between UBE2T expression and clinicopathological features (age， T stage， N stage， M stage， pathological type and recurrence) and prognosis of lung cancer were analyzed. Gene enrichment analysis (GSEA) was used to analyze genes regulated by UBE2T. Results The expression level of UBE2T in lung cancer tissues was 1.222±0.1214，higher than -1.645±0.0783 of normal bladder tissues， and the difference was statistically significant (P＜0.05). The expression of UBE2T in lung cancer tissues was related to T stage， N stage， pathological analysis and recurrence (P<0.05)， but not related to gender， age and M stage (P>0.05). The 5-year overall survival rate and 5-year disease-free survival rate of UBE2T high expression group were 32.672% and 27.513%， lower than 66.767% and 62.019% in the low-expression group， and the difference was statistically significant (P＜0.05). GSEA results showed that UBE2T highly expressed samples enriched MYC signaling pathway， DNA repair factor， mitotic spindle， G2M checkpoint， mTORC1 complex， E2F transcription factor and mitotic related gene sets. Conclusion UBE2T is highly expressed in lung cancer tissues and is related to many clinicopathological features of lung cancer. UBE2T could be considered as a potential marker and target in the diagnosis and treatment of lung cancer.

Key words

Lung cancer / Ubiquitin-conjugating enzyme E2T / Gene Expression Omnibus / Clinical significance / Prognosis

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LI Wei， GUO Zi-xing， LI Yong-hong， LIU Xiao-ping， HUANG Jing-yu， HU Wei-dong， LI Sheng. Analysis of expression and its clinical significance of UBE2T in lung cancer based on GEO database[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(2): 242-245 https://doi.org/10.16689/j.cnki.cn11-9349/r.2019.02.017

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