Meta-analysis of the effects of glutamine on postoperative complications， immune function and nutritional status of colorectal cancer

JIN Xin; HU Ren-chong; TIAN Meng-xing; XU Xin-tian; LI Hong-xia; DAI Zhu; YANG Hui

doi:10.16689/j.cnki.cn11-9349/r.2019.02.018

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2019, Vol. 6 ›› Issue (2) : 246-255. DOI: 10.16689/j.cnki.cn11-9349/r.2019.02.018

Meta-analysis of the effects of glutamine on postoperative complications， immune function and nutritional status of colorectal cancer

1 JIN Xin，1 HU Ren-chong， 1 TIAN Meng-xing， 2XU Xin-tian，2 LI Hong-xia， 2 DAI Zhu， 3YANG Hui

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Abstract

Objective explore the effect of perioperative glutamine supplementation on postoperative complications， nutritional status and immune function of colorectal cancer. Methods All randomized controlled trials that met the inclusion criteria from the default time to October 2018 were retrieved from the following databases: Pubmed， Medline， Embase， Cochrane Library， Chinese biomedical literature database (CBM)， Chinese journal full text database (CNKI)， and Wanfang database. Meta-analysis was performed on the included studies after screening. Results A total of 22 articles were included， including 1，466 patients. Meta-analysis indicated perioperative supplement glutamine can prevent anastomotic fistula， shorten the length of hospital stay， adjust the immune function related indicators such as IgG， IgM， IgA， CD4， CD4/CD8， up-regulate nutrition-related biochemical indicators such as albumin， prealbumin and reduce the level of serum inflammatory factor TNF-α. However， there were also no significant differences between the two groups on postoperative incision infection and pulmonary infection complications. Conclusion Glutamine supplementation during the perioperative period of colorectal cancer plays a certain role in preventing anastomotic fistula， improving postoperative immune function and shortening hospitalization time， but there is insufficient evidence for preventing infectious complications and improving nutritional status.

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Glutamine / Colorectal cancer / Postoperative complications / Immune function / Nutritional status

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JIN Xin， HU Ren-chong， TIAN Meng-xing， XU Xin-tian，LI Hong-xia， DAI Zhu， YANG Hui. Meta-analysis of the effects of glutamine on postoperative complications， immune function and nutritional status of colorectal cancer[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(2): 246-255 https://doi.org/10.16689/j.cnki.cn11-9349/r.2019.02.018

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