ABD bioactives alleviates chemotherapy-induced myelosuppression

1*LUO Min; 2*WU Xiao-jun; 2ZHANG Xin; 3DONG Guang; 4XIONG Li-long; 4WANG Peng-cheng; 1GAO Kui; 1YU Ping; 1HE Mei; 5DU Chi; 5JIANG Ou; 6SHI Han-ping

doi:10.16689/j.cnki.cn11-9349/r.2019.03.015

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2019, Vol. 6 ›› Issue (3) : 346-350. DOI: 10.16689/j.cnki.cn11-9349/r.2019.03.015

ABD bioactives alleviates chemotherapy-induced myelosuppression

1*LUO Min， 2*WU Xiao-jun， 2ZHANG Xin， 3DONG Guang， 4XIONG Li-long， 4WANG Peng-cheng， 1GAO Kui， 1YU Ping， 1HE Mei， 5DU Chi， 5JIANG Ou， 6SHI Han-ping

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Abstract

Objective To explore the effect of ABD bioactives on myelosuppression alleviation in lung cancer patients during chemotherapy. Methods 44 lung cancer patients who received chemotherapy were randomly divided into intervention group and control group. 22 lung patients in intervention group received ABD Bioactives for adjuvant therapy. 22 lung cancer patients were treated conventionally. The difference of myelosuppression was compared between the two groups. Results 43 patients completed chemotherapy as planned， and 1 patients of the control group terminated chemotherapy due to severe myelosuppression. Myelosuppression of intervention group was significantly alleviated (P<0.05). The incidence of myelosuppression of Ⅲ~Ⅳ was significantly lower (P<0.05)， and the inhibition of leukocytes， granulocytes and platelets was significantly alleviated (P<0.05，P<0.05，P<0.05) compared with the control group. The myelosuppression induced by paclitaxel +platinum-based agents， pemetrexed+ platinum-based agents was significantly alleviated (P<0.05，P<0.05，P<0.05，P<0.05) compared with the control group. Conclusion ABD Bioactives can alleviate chemotherapy-induced myelosuppression in lung cancer patients， especially reduce the incidence of Myelosuppression of Ⅲ~Ⅳ， increase the levels of leukocytes， granulocytes and platelets， reduce the toxicity and side effects of platinum-based agents， paclitaxel， antimetabolite.

Key words

Myelosuppression / ABD Bioactives / Glutathione / Nutritional therapy / Clinical risk management

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1*LUO Min， 2*WU Xiao-jun， 2ZHANG Xin， 3DONG Guang， 4XIONG Li-long， 4WANG Peng-cheng， 1GAO Kui， 1YU Ping， 1HE Mei， 5DU Chi， 5JIANG Ou， 6SHI Han-ping. ABD bioactives alleviates chemotherapy-induced myelosuppression[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(3): 346-350 https://doi.org/10.16689/j.cnki.cn11-9349/r.2019.03.015

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