Changes and correlation analysis of serum leptin and adiponectin expression in patients with gastric and colorectal cancer

1MA Cui-cui; 2LI Yang; 3PANG Xiang-peng; 3LOU Ting-ting; 1WANG Huan; 1GUO Rui-fang; 4LIU Ya-hang

doi:10.16689/j.cnki.cn11-9349/r.2019.03.016

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2019, Vol. 6 ›› Issue (3) : 351-356. DOI: 10.16689/j.cnki.cn11-9349/r.2019.03.016

Changes and correlation analysis of serum leptin and adiponectin expression in patients with gastric and colorectal cancer

1MA Cui-cui， 2LI Yang， 3PANG Xiang-peng， 3LOU Ting-ting，1WANG Huan， 1GUO Rui-fang， 4LIU Ya-hang

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Abstract

Objective To determine the changes of serum leptin and adiponectin levels in patients with gastric cancer and colorectal cancer and their correlation with pathogenesis. Methods A total of 53 patients with gastric cancer， 48 patients with colorectal cancer， and 56 patients with non-tumor control were enrolled in the period from April 1， 2015 to January 31， 2016. Serum leptin and adiponectin were detected. Serum leptin and adiponectin expression in gastric cancer， colorectal cancer and non-tumor control groups were compared， and relative risk and correlation analysis were performed. Result After comparing the demographic characteristics and disease characteristics， the three groups of patients were found that have significant difference in gender (χ2=27.353， P=0.000)， age (χ2=9.953， P=0.007)， and education level (χ2=27.527， P=0.000)， the family history of the tumor (χ2=133.503， P=0.000). Compared with the non-tumor control group， the serum leptin expression level was increased in the gastric cancer group ［(6.02±1.83) vs (4.76±1.62)， P=0.013］， and the serum leptin expression level was increased in the colorectal cancer group ［(6.21±1.74) vs (4.76±1.62)， P=0.006］； serum adiponectin expression decreased in patients with gastric cancer ［(4.43±0.48) vs (4.90±0.39)， P=0.000］， and serum adiponectin expression decreased in patients with colorectal cancer ［(4.41±0.42) vs (4.90±0.39)， P=0.000］. The data were stratified by pathological classification， and there was no statistical difference between the three groups of high， medium and low differentiation. There were no statistical differences between the two groups in the early and middle-stage tumors. The serum leptin levels and adiponectin levels in the gastric cancer， colorectal cancer and non-tumor control groups were stratified by quartiles， and the relative risk analysis was performed. The serum leptin odds ratio (OR) of gastric cancer and colorectal cancer group OR values were 3.51 and 9.23， and the serum adiponectin OR values were 0.20 and 0.07. Conclusion Elevated serum leptin level is a risk factor for gastric cancer and colorectal cancer. Serum adiponectin level is a protective factor for gastric cancer and colorectal cancer， but the decrease of serum adiponectin level will increases gastric cancer and colorectal cancer’s risk of onset. Changes in serum leptin and adiponectin levels may be associated with the pathogenesis of gastric cancer and colorectal cancer.

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Gastric cancer / Colorectal cancer / Lipid metabolism / Leptin / Adiponectin

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1MA Cui-cui， 2LI Yang， 3PANG Xiang-peng， 3LOU Ting-ting，1WANG Huan， 1GUO Rui-fang， 4LIU Ya-hang. Changes and correlation analysis of serum leptin and adiponectin expression in patients with gastric and colorectal cancer[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(3): 351-356 https://doi.org/10.16689/j.cnki.cn11-9349/r.2019.03.016

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