Research progress on the relationship between intestinal microecology and tumorigenesis and development

Chen Fei; Liang Tingting; Lyu Zheng; Li Wei; Cui Jiuwei

doi:10.16689/j.cnki.cn11-9349/r.2020.01.002

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (1) : 7-12. DOI: 10.16689/j.cnki.cn11-9349/r.2020.01.002

Research progress on the relationship between intestinal microecology and tumorigenesis and development

Chen Fei, Liang Tingting, Lyu Zheng, Li Wei, Cui Jiuwei

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Abstract

There are many types of intestinal microbes, which form a complex intestinal microecosystem. The intestinal microecosystem co-exists with the host and affects the hosts health, and it is known as the "second genome" of human beings. Intestinal microecological imbalance is closely related to the occurrence and development of malignant tumors. The current research results show that changes in the diversity and abundance of intestinal microorganisms including bacteria, fungi and viruses are related to tumorigenesis and its development. These microorganisms can affect tumors by regulating host inflammation and immunity, participating in material metabolism, and disrupting gene stability process. However, there are significant differences in the results of various studies, which may be related to various factors such as inconsistent research methods and the complexity of intestinal microorganisms. Regulation of intestinal microecology through diet therapy, supplementation of probiotics or missing bacteria, and application of antibiotics may become new methods for tumor prevention and treatment. This article summarizes the current research progress on the relationship between intestinal microecology and the occurrence and development of malignant tumors. Also, it points out some challenges and possible solutions for intestinal microbiological research in the field of oncology, as well as the new direction of tumor prevention and treatment targeting intestinal microecology in the future. The review aims to clarify the ideas for further tumor-microbial research and accelerate the clinical transformation of the research results, and provide new strategies for tumor diagnosis and treatment.

Key words

Intestinal microbiome / Malignant tumor / Occurrence / Development / Challenge

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Chen Fei, Liang Tingting, Lyu Zheng, Li Wei, Cui Jiuwei. Research progress on the relationship between intestinal microecology and tumorigenesis and development[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(1): 7-12 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.01.002

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