Prognostic significance of prognostic nutritional index in advanced colorectal cancer with third-line therapy

Li Yiming; Zou Man; Zhuang Liang; Zou Yanmei; Zhang Mingsheng; Qiu Hong; Dai Yuhong

doi:10.16689/j.cnki.cn11-9349/r.2020.02.014

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (2) : 209-213. DOI: 10.16689/j.cnki.cn11-9349/r.2020.02.014

Prognostic significance of prognostic nutritional index in advanced colorectal cancer with third-line therapy

Li Yiming， Zou Man， Zhuang Liang， Zou Yanmei， Zhang Mingsheng， Qiu Hong， Dai Yuhong

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Abstract

Objective To investigate the prognostic value of prognostic nutritional index （PNI） in the advanced colorectal cancer patients of third-line therapy. Methods Clinical data of 43 advanced colorectal cancer patients were retrospectively analysed， who were treated with S-1 plus apatinib as third-line therapy. PNI（prognostic nutritional index）， AGR（albumin-to-globulin ratio）， PLR （platelet lymphocyte ratio）and LMR（lymphocyte monocyte ratio） were calculated. Cox proportional hazards regression models and Kaplan-Meier curve were used to evaluate the impact on survival. Results According to receiver operating characteristic （ROC） curves， the cutoff value for PNI was 47.08； the result of univariate analysis showed PNI， AGR， ECOG， HGB， NLR and LMR were significantly correlated with overall survival （OS）； multivariate analysis showed that ECOG and PNI were independent prognostic factor of OS. The median overall survival for PNI-low patients were 5.70months（95%CI=4.42-6.98）， while the mOS for PNI-high patients were 15.77months（95%CI=7.43-24.1），P=0.000.The mPFS for PNI-low and PNI-high patients were 3.42months（95%CI=2.31-4.53）and 6.29months（95%CI=4.96-7.62）respectively，P=0.003. Conclusion PNI could be a useful prognostic indicator for advanced colorectal cancer patients who received the combination of S1 plus apatinib as third-line treatment.

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Colorectal cancer / Prognostic nutritional index / Prognostic factor

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Li Yiming， Zou Man， Zhuang Liang， Zou Yanmei， Zhang Mingsheng， Qiu Hong， Dai Yuhong. Prognostic significance of prognostic nutritional index in advanced colorectal cancer with third-line therapy[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(2): 209-213 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.02.014

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