Study on the intervention of individualized nutrition therapy in patients with postoperative chemotherapy of gastric cancer and the analysis of factors affecting their quality of life

Zhang Wenrong; Han Ying; Deng Hailian; Zhang Lijuan

doi:10.16689/j.cnki.cn11-9349/r.2020.02.018

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (2) : 231-235. DOI: 10.16689/j.cnki.cn11-9349/r.2020.02.018

Study on the intervention of individualized nutrition therapy in patients with postoperative chemotherapy of gastric cancer and the analysis of factors affecting their quality of life

Zhang Wenrong， Han Ying， Deng Hailian， Zhang Lijuan

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Abstract

Objective To investigate the influencing factors of quality of life and individualized nutritional intervention in patients with gastric cancer after chemotherapy. Methods From January 2017 to January 2019， 100 patients admitted to Beijing Rehabilitation Hospital Affiliated to Capital Medical University were divided into the observation group （n=50） and the control group （n=50） given different nutritional intervention. The patients in the observation group were treated with individualized nutrition intervention， while the control group was treated with routine nutrition intervention. The changes of body mass index， nutrition index and peripheral blood index， the probability of complications and the score of quality of life in the two groups were compared before and after chemotherapy， and the factors affecting the quality of life of patients with gastric cancer after chemotherapy were analyzed by multivariate Logistic regression analysis. Results The body mass index （BMI）， nutrition index （PNI）， prealbumin （PALB）， serum albumin （ALB） and transferrin （TRF） were significantly higher in the observation group than those in the control group. After nutritional intervention， BMI and TRF in the two groups showed an upward trend compared with those before chemotherapy， and the difference was statistically significant（P<0.05）. The probability of complications was significantly lower in the observation group than in the control group.（ χ2=4.336，P=0.037）. After chemotherapy， the scores of overall health status in the two groups were significantly higher than those in the control group， while the scores in the three symptom areas in the observation group were significantly higher than those in the control group（P<0.05）. Logistic regression analysis found that lymph node metastasis， monthly household income ≤5000 yuan， combined organ resection， rural residence and malnutrition were the main factors affecting the quality of life of gastric cancer patients after chemotherapy. Conclusion Lymph node metastasis， working condition， combined organ resection， surgical scope and nutritional status have important effects on the quality of life of patients with gastric cancer after chemotherapy. Individualized nutrition intervention can promote the improvement of physical indexes of patients with gastric cancer after chemotherapy， which is beneficial to improve the quality of life of patients with gastric cancer.

Key words

Gastric cancer / Chemotherapy / Quality of life / Influencing factors / Individualized nutritional intervention

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Zhang Wenrong， Han Ying， Deng Hailian， Zhang Lijuan. Study on the intervention of individualized nutrition therapy in patients with postoperative chemotherapy of gastric cancer and the analysis of factors affecting their quality of life[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(2): 231-235 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.02.018

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