Expert consensus on hyperhomocysteinemia#br#

Bone Health and Nutrition Branch of Chinese Nutrition Society; Chinese Society of Parenteral and Enteral Nutrition; North Chronic Disease Prevention and Treatment Branch of Chinese Geriatric Society

doi:10.16689/j.cnki.cn11-9349/r.2020.03.007

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (3) : 283-288. DOI: 10.16689/j.cnki.cn11-9349/r.2020.03.007

Expert consensus on hyperhomocysteinemia#br#

Bone Health and Nutrition Branch of Chinese Nutrition Society, Chinese Society of Parenteral and Enteral Nutrition, North Chronic Disease Prevention and Treatment Branch of Chinese Geriatric Society

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Abstract

High homocysteine levels, and a variety of disease development, such as cardiovascular disease, hypertension, diabetes, and closely related diseases such as kidney disease, pregnancy, almost affect the whole body organs, through oxidative damage, DNA methylation and metabolic abnormalities and other mechanism of sulfur compound affect cell function, protein synthesis and regulation, leading to the pathological changes of tissues and organs. Currently, there is no guideline for the diagnosis and treatment of demographic characteristics in China. This expert consensus is based on the review and analysis of research literature and evidence-based medicine at home and abroad in the past 30 years, combined with the characteristics of the Chinese population, recommending that tHcy ≥ 10μmol/L is defined as hyperhomocysteinemia. By adjusting the diet composition and / or using dietary supplements such as betaine, vitamins B and related coenzyme nutritional supplements, the level of tHcy can be prominently reduced, which is expected to significantly slow down the development of related diseases. It is recommended to carry out the detection indicators related to homocysteine, so as to clarify the causes of homocysteine rise, to guide the clinical precise intervention measures, effectively to improve the level of homocysteine, and to achieve the purpose of preventing the occurrence of diseases or delaying the progress of diseases.

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Bone Health and Nutrition Branch of Chinese Nutrition Society, Chinese Society of Parenteral and Enteral Nutrition, North Chronic Disease Prevention and Treatment Branch of Chinese Geriatric Society. Expert consensus on hyperhomocysteinemia#br#[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(3): 283-288 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.007

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