Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients

Wu Ping; Du Renjia; Yu Yun; Ge Xiaosong

doi:10.16689/j.cnki.cn11-9349/r.2020.03.012

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (3) : 312-316. DOI: 10.16689/j.cnki.cn11-9349/r.2020.03.012

Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients

Wu Ping1, Du Renjia1, Yu Yun1,Ge Xiaosong2

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Abstract

Objective The prognostic nutritional index(PNI) is used as a prognostic factor in gastric cancer(GC). Through this retrospective study, we aim to investigate the relationship between the postoperative PNI and prognosis of patients with stage Ⅲ GC. Methods The subjects of this retrospective study were 91 patients who underwent resection for stage Ⅲ GC, according to the first chemotherapy after surgery, calculated nutrient comprehensive index, such as PNI, NLR, PLR, SII. Time-dependent receiver operating characteristic curve analyses were used to assess discrimination ability and to determine the optimal cut-off values. Results According to the optimal cut-off value, they were divided into the low PNI group (PNI<42.3) and the high PNI group (PNI≥42.3).According to the staging, they were divided into Ⅲa, Ⅲb and Ⅲc three substages. All the inflammation-based and/or the nutritional markers of patients of stage Ⅲ GC, multivariate analyses demonstrated PNI and staging were independent prognostic factors for OS (P=0.004 and P=0.009, respectively). Conclusion PNI is an independent prognostic factor for the prognosis of postoperative chemotherapy patients with gastric cancer, and low PNI and high sub-staging were associated with poor prognosis.

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Wu Ping, Du Renjia, Yu Yun,Ge Xiaosong. Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(3): 312-316 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.012

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