Research progress on lactatedehydrogenase and immunometabolism in cancer

Zhou Wenli; Miao Mingyong

doi:10.16689/j.cnki.cn11-9349/r.2020.04.004

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 396-401. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.004

Research progress on lactatedehydrogenase and immunometabolism in cancer

Zhou Wenli1, Miao Mingyong 2

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Abstract

The metabolic characteristics are different in different immune cell subsets. The immune cells in antitumor adaptive immunity mainly rely on aerobic glycolysis and glutamine catabolism to obtain energy and metabolites. Immunosuppressive cells in promoting cancer occurrence and progression can use the metabolites from cancer cells to get energy and intermediate products through fatty acid metabolism or other manners. As the critical product of glycolysis, lactic acid directly or indirectly affects the biological behavior of cancer and immunometabolism in tumor microenvironment. Lactate dehydrogenase （LDH） is a key enzyme connecting the metabolism of immune cells by lactic acid metabolism, generally with high expression in cancers, which regulates immune response and participates in carcinogenesis and development by activating some signal transduction pathway. It is identified as an important driver of immunosuppressive microenvironment. The increase of LDH level is mainly caused by the increase of glycolysis activity and hypoxia necrosis in cancer. To some extent, the levels of LDH can reflect and be used for the assessment of glycolysis activity and immune metabolism. However, the roles of LDH in immunometabolic regulation varies in different immune cells such as T lymphocytes, macrophages and dendritic cells. This paper reviews the researches on LDH and metabolism of these immune cells to explore the possible application in evaluating prognosis, predicting and monitoring efficacy of anti-tumor treatment, especially in cancer immunotherapy.

Key words

Lactate dehydrogenase / Glycolysis / Tumor immune metabolism / Immunotherapy / Efficacy prediction

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Zhou Wenli, Miao Mingyong. Research progress on lactatedehydrogenase and immunometabolism in cancer[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 396-401 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.004

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