Research progress of drug therapy for cancer cachexia

Wang Lin

doi:10.16689/j.cnki.cn11-9349/r.2020.04.005

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 402-406. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.005

Research progress of drug therapy for cancer cachexia

Wang Lin

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Abstract

Cancer cachexia mainly contains the gradual decrease of muscle mass, anorexia, fatigue, and impaired functional status, which seriously affects the quality of life and survival time of patients. Among them, gastrointestinal and pulmonary malignancies are the most common. Drug therapy plays an important role in the comprehensive treatment, but currently the more commonly used drugs, such as appetite stimulants and some drugs to control symptoms, have unsatisfactory efficacy. In recent years, many metabolic regulators, targeted drugs and traditional Chinese medicine have shown good efficacy and tolerance in the treatment of cancer cachexia, such as ghrelin analogues, which promote growth and anabolic metabolism, and monoclonal antibodies which inhibit catabolic metabolism. The treatment of cachexy requires comprehensive intervention of clinical multidisciplinary collaboration, which can be controlled and even reversed. We made a comprehensive review on the progression of current drug therapy for cancer cachexia.

Key words

cancer cachexia / Drug therapy / Metabolic regulation / Ghrelin

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Wang Lin. Research progress of drug therapy for cancer cachexia[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 402-406 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.005

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