Research status of the mechanism of intestinal barrier function injury and its clinical detection methods

Yu Haobin; Zhang Xiaodan; Li Suyi

doi:10.16689/j.cnki.cn11-9349/r.2020.04.006

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 407-414. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.006

Research status of the mechanism of intestinal barrier function injury and its clinical detection methods

Yu Haobin1,Zhang Xiaodan 2, Li Suyi2

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Abstract

As the digestive organ of the body, the intestinal tract not only has the functions of digestion, absorption and peristalsis, but also has the functions of endocrine, immune regulation and mucosal barrier. The intestinal barrier function under physiological conditions can digest and absorb nutrients, effectively prevent the internal environment from being harmed by harmful substances, ensure the stability of internal environment, it consists of mechanical barrier, immune barrier, chemical barrier and biological barrier. The mechanism of intestinal barrier function damage is complex, and a variety of clinical factors can directly or indirectly damage intestinal barrier function, including severe infection, trauma, burn, intestinal obstruction, acute pancreatitis, severe malnutrition, severe blood loss, fluid loss, long-term application of broad-spectrum antibiotics or immunosuppressive agents, ionizing radiation, radiotherapy, chemotherapy, etc. These factors can lead to impaired intestinal barrier function in one or more ways, causing vertical translocation of intestinal pathogenic microorganisms and their metabolites into the blood through the portal vein and lymphatic system, causing bacteremia and toxaemia, and in severe cases, leading to systemic inflammatory response syndrome and multi-system organ failure. At present, the level of D-lactic acid, diamine oxidase and endotoxin in blood are mostly used to evaluate the intestinal barrier function. Attention should be paid to the treatment of intestinal barrier dysfunction in clinical work. In this paper, the mechanism, diagnosis and treatment of intestinal barrier and its injury are reviewed.

Key words

Intestinal barrier function / Diamine oxidase / Endotoxin / D-lactic acid

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Yu Haobin,Zhang Xiaodan, Li Suyi. Research status of the mechanism of intestinal barrier function injury and its clinical detection methods[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 407-414 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.006

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