Randomized controlled trial of application of antibiotic lock technique in preventing implantable venous access port-related infection in infants

Yu Haijiao; Zhu Yubing; Li Wenxia; Zhao Aimin; Ding Lei; Gao Hong; Ma Ling

doi:10.16689/j.cnki.cn11-9349/r.2020.04.010

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 428-432. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.010

Randomized controlled trial of application of antibiotic lock technique in preventing implantable venous access port-related infection in infants

Yu Haijiao, Zhu Yubing, Li Wenxia, Zhao Aimin, Ding Lei, Gao Hong, Ma Ling

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Abstract

Objective This research was designed to explore the effect of antibiotic lock technique (ALT) in preventing implantable venous access port (IVAP)-related infection in infants with malignant tumors. MethodsSixty infants with neurological malignant tumors were underwent implantation of IVAP by the same surgical team in our hospital. They were randomly divided into two groups. Prophylactic cefuroxime mixed with heparin saline was used as the seal liquid in 30 infants after the implantation, and the same volume of heparin saline was applied in the other 30 infants. All the patients were followed to observe whether there was IVAP-related infection within one month. The differences between two groups were compared and the risk factors for IVAP were investigated. ResultsThe general characteristics had no significant difference between two groups. Only one infant got infection in the ALT group (3.33%), while four infants developed infection in the control group (13.33%). Although the difference between two groups was not statistically significant (P=0.353). No significant independent risk factor for IVAP was revealed by the present study. ConclusionThe application of ALT in the IVAP implantation might be an effective method to decrease the infection rate in infants with malignant tumors to a large extent, but it still needs a large sample of research to confirm the clinical effect.

Key words

Implantable venous access port / Infants with malignant tumors / Antibiotic lock technique / Catheter related infection

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Yu Haijiao, Zhu Yubing, Li Wenxia, Zhao Aimin, Ding Lei, Gao Hong, Ma Ling. Randomized controlled trial of application of antibiotic lock technique in preventing implantable venous access port-related infection in infants[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 428-432 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.010

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