The clinical value of modified Glasgow prognosis score in predicting the prognosis of advanced pancreatic cancer

Liu Yiqian; Wang Jian; Liu Lingxiang; Shu Yongqian

doi:10.16689/j.cnki.cn11-9349/r.2020.04.012

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 438-442. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.012

The clinical value of modified Glasgow prognosis score in predicting the prognosis of advanced pancreatic cancer

Liu Yiqian1 , Wang Jian2 , Liu Lingxiang1, Shu Yongqian 1

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Abstract

ObjectiveTo investigate the effect of modified Glasgow prognosis score (mGPS) on the survival of patients with advanced pancreatic cancer, and to evaluate its potential clinical value in the prognosis of advanced pancreatic cancer. MethodsThe clinical data of 56 patients with advanced pancreatic cancer treated in the Department of oncology and gastroenterology, the First Affiliated Hospital of Nanjing Medical University from January 2015 to December 2018 were retrospectively analyzed. The relationship between mGPS, clinical features and prognosis was analyzed. Kaplan Meier method was used to draw survival curve, log-rank was used for univariate analysis, and Cox proportional hazard model was used for multivariate analysis to analyze the prognostic factors affecting poor prognosis of patients with advanced pancreatic cancer. Results Among the 56 patients, 32 were male and 24 were female. There were 29, 21 and 6 patients with mGPS score of 0, 1 and 2 respectively. Univariate analysis showed that age ≥ 65 years (P=0.035), high mGPS score (P<0.001) and no chemotherapy (P<0.001) were risk factors for OS in patients with advanced pancreatic cancer. Further multivariate Cox regression analysis showed that age ≥ 65 years (P=0.021), mGPS score of 2 (P<0.001) and non chemotherapy (P<0.001) were independent poor prognostic factors of advanced pancreatic cancer. Conclusion mGPS has important clinical significance in evaluating the prognosis of patients with advanced pancreatic cancer. High mGPS score indicates poor prognosis.

Key words

Pancreatic cancer / Modified Glasgow prognostic score / Treatment outcome / Prognosis

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Liu Yiqian,Wang Jian,Liu Lingxiang, Shu Yongqian. The clinical value of modified Glasgow prognosis score in predicting the prognosis of advanced pancreatic cancer[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 438-442 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.012

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