Research progress of antitumor effects and mechanisms of selenite

Li Yushan; Zhou Lan

doi:10.16689/j.cnki.cn11-9349/r.2020.04.022

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 490-496. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.022

Research progress of antitumor effects and mechanisms of selenite

Li Yushan, Zhou Lan

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Abstract

Selenium is an important trace element required by the human body and is closely related to human health and diseases.In recent years, selenium and its compounds have attracted widespread attention for their highly selective cytotoxicity against tumor cells. Selenite, as the most common and studied inorganic selenide in nature, is generally regarded as a pro-oxidant to kill tumor cells. Selenite can react with intracellular thiols to mediate the production of reactive oxygen species, oxidize sulfhydryl groups in related proteins involved in metabolism, transcription, signal transduction, and change its biological activity to inhibit tumor cell proliferation, but its effects of anti-cancer are far more than that. Studies have reported that selenite can regulate these mechanisms to play a role in tumor suppression： inhibiting related enzyme activities and regulating metabolic genes to interfere with tumor nutrient metabolism, activating endogenous and exogenous apoptosis pathways, regulating the epigenetic modification of tumor suppressor genes or oncogenes, being converted into endogenous selenium nanoparticles to mediate cytotoxicity, stimulating immune cells division and activation and assisting in identifying tumor antigens, etc. Further strengthening the research and understanding of the anti-tumor effect of selenite can not only provide certain evidence for the development of new clinical drugs, but also provide new treatment ideas for clinical oncologists, which is of great significance for improving the effect of tumor treatment. This review aims to summarize the research progress of the antitumor effects and mechanisms of selenite.

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Selenite / Tumor / Anti-tumor effect / Cell death / Molecular mechanism

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Li Yushan, Zhou Lan. Research progress of antitumor effects and mechanisms of selenite[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 490-496 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.022

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