Research progress of QCT in quantitative diagnosis of cancer cachexia syndrome and evaluation of curative effect

Chen Dong; Wang Chuanbin; Shi Bin; Gao Fei; Dong Jiangning

doi:10.16689/j.cnki.cn11-9349/r.2020.04.023

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2020, Vol. 7 ›› Issue (4) : 497-501. DOI: 10.16689/j.cnki.cn11-9349/r.2020.04.023

Research progress of QCT in quantitative diagnosis of cancer cachexia syndrome and evaluation of curative effect

Chen Dong, Wang Chuanbin, Shi Bin, Gao Fei, Dong Jiangning

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Abstract

The changes in body composition of cancer patients during treatment are affected by many factors and are closely related to the poor prognosis of patients. Patients with advanced malignant tumors are often accompanied by cachexia, which seriously affects the patients quality of life and prognosis. The pathogenesis of cancer cachexia has not been elucidated. Changes in the body composition of patients with early cancer cachexia often have certain hints and early warning significance for the clinicians. In the past, the BMI was used to assess cachexia, ignoring changes in muscle fat content and abnormal fat infiltration, and it was impossible to accurately quantify body components. Quantitative computed tomography (QCT) can comprehensively, accurately and efficiently quantify the patients muscle density, bone mineral density (BMD) and body fat content, etc. which can be used as relevant indicators for evaluating the patients nutritional status, and those relevant information has great advantages in evaluating cancer cachexia. The author summarizes quantitative diagnosis of cachexia and the application progress of QCT in evaluating the efficacy of cancer treatment based on changes in body composition are reviewed, aiming to improve the application value of QCT in the diagnosis and efficacy evaluation of cancer cachexia.

Key words

Quantitative computed tomography / Malignant tumor / Cachexia / Diagnosis / Therapeutic effect evaluation

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Chen Dong, Wang Chuanbin, Shi Bin, Gao Fei, Dong Jiangning. Research progress of QCT in quantitative diagnosis of cancer cachexia syndrome and evaluation of curative effect[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(4): 497-501 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.04.023

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