Multidimensional exploration of exercise therapy from the perspective of gastrointestinal cancer prevention and treatment

Zhang Xikai, Wang Kaifeng

Electronic Journal of Metabolism and Nutrition of Cancer ›› 2026, Vol. 13 ›› Issue (1) : 20-25.

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2026, Vol. 13 ›› Issue (1) : 20-25. DOI: 10.16689/j.cnki.cn11-9349/r.2026.01.004
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Multidimensional exploration of exercise therapy from the perspective of gastrointestinal cancer prevention and treatment

  • 1Zhang Xikai, 1,2Wang Kaifeng
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Abstract

In recent years, malignant tumors have increasingly become a major public health problem endangering human life and health.Both the overall incidence and mortality of digestive tract tumors are in the forefront of the proportion of malignant tumors, which needs further attention. How to improve the survival time and quality of life of cancer patients is an urgent problem. In addition to surgery, chemotherapy, radiotherapy, immunotherapy and other means, the role of exercise therapy in the treatment of gastrointestinal tumors has received more and more attention. Previous studies have preliminarily revealed multiple possible biological mechanisms by which exercise affects gastrointestinal tumors. Exercise therapy can play an important role in the tertiary prevention of gastrointestinal tumors, which not only involves the primary prevention to reduce the incidence and the secondary prevention to increase the efficiency of adjuvant therapy, but also shows a significant effect in the tertiary prevention to reduce tumor recurrence and metastasis. When formulating exercise prescription, we should first carry out risk assessment, comprehensively consider the patients' nutritional status, physical fitness level, exercise risk assessment and the results of exercise ability test. The exercise prescription should cover aerobic exercise, resistance exercise and flexibility exercise, and carry out the corresponding exercise combination according to the results of comprehensive evaluation. After formulating exercise prescription, patients with gastrointestinal cancer need to implement exercise prescription under the supervision of relevant personnel, and pay attention to the individualization and timely adjustment of exercise prescription. At present, there are still many challenges in the implementation of the clinical transformation of exercise therapy. Developing unified exercise intervention standards and guidelines, helping patients make personalized exercise plans with the help of digital medical tools, and establishing a multidisciplinary collaboration model are some of the future development directions.We hope that through a series of multi-dimensional efforts, we can promote the implementation of exercise therapy in the whole process management of patients with gastrointestinal cancer, so that more patients can benefit.

Key words

Digestive tract tumors / Exercise therapy / Mechanism / Prevention / Treatment / Rehabilitation / Evaluation / Exercise prescription

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Zhang Xikai, Wang Kaifeng. Multidimensional exploration of exercise therapy from the perspective of gastrointestinal cancer prevention and treatment[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2026, 13(1): 20-25 https://doi.org/10.16689/j.cnki.cn11-9349/r.2026.01.004

References

[1] BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3):229-263.
[2] HAN B, ZHENG R, ZENG H, et al. Cancer incidence and mortality in China, 2022[J]. J Natl Cancer Cent, 2024, 4(1):47-53.
[3] 徐瑞华, 李进, 江泽飞. 中国临床肿瘤学年度研究进展[M]. 北京:人民卫生出版社, 2023:317.
[4] LI X, ZHAO J, YE G, et al. Establishment and real-world application of an adverse reaction monitoring system for targeted therapy of antitumor drugs[J]. Oncol Treat Discov, 2025, 3(3):24-29.
[5] 丛明华. 肿瘤运动疗法[J/CD]. 肿瘤代谢与营养电子杂志,2025,12(4):405-408.
[6] KOWARIK E., WIRTZ P., BAUMANN F. T. Access of oncological patients to exercise therapy parallel to treatment-a questionnaire-based survey in German cancer centres[J]. Oncol Res Treat, 2017, 40(5):264-271.
[7] MCTIERNAN A, FRIEDENREICH C M, KATZMARZYK P T, et al. Physical Activity in Cancer Prevention and Survival: A Systematic Review[J]. Med Sci Sports Exerc, 2019, 51(6):1252-1261.
[8] MCGOWAN E L, SPEED-ANDREWS A E, RHODES R E, et al. Sport participation in colorectal cancer survivors: an unexplored approach to promoting physical activity[J]. Support Care Cancer, 2013, 21(1):139-147.
[9] KALEEM M, AZMI L, SHAHZAD N, et al. Epigenetic dynamics and molecular mechanisms in oncogenesis, tumor progression, and therapy resistance[J]. Naunyn Schmiedebergs Arch Pharmacol, 2025, 398(10):2367-2388.
[10] JOMOVA K, ALOMAR Y S, VALKO R, et al. Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression[J]. Arch Toxicol, 2025, 99(8):2195-2241.
[11] CHUANMEI Z, HONGBO M, ANQI H, et al. Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information[J]. Cancer Lett, 2022, 544:215814.
[12] HOJMAN P, GEHL J, CHRISTENSEN F J, et al. Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment[J]. Cell Metab, 2018, 27(1):10-21.
[13] ROGERS C J, BERRIGAN D, ZAHAROFF D A, et al. Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice[J]. J Nutr, 2008, 138(1):115-122.
[14] KOELWYN G J, QUAIL D F, ZHANG X, et al. Exercise-dependent regulation of the tumour microenvironment[J]. Nat Rev Cancer, 2017, 17(10):620-632.
[15] GAO X, ZHANG P. Exercise perspective: benefits and mechanisms of gut microbiota on the body[J]. J Cent South Univ Med Sci, 2024, 49(4):508-515.
[16] LIU X, XU M, WANG H, et al. Role and mechanism of short-chain fatty acids in skeletal muscle homeostasis and exercise performance[J]. Nutrients, 2025, 17(9):1463.
[17] WILEY B, C N P, OWEN C, et al. The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level[J]. Gut, 2018, 67(4):625-633.
[18] SHEN Z, YE Y, BIN L, et al. Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis[J]. Am J Surg, 2010, 200(1):59-63.
[19] FARVID M S, SIDAHMED E, SPENCE N D, et al. Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies[J]. Eur J Epidemiol, 2021, 36(9):937-951.
[20] EAGLEHOUSE Y L, KOH W P, WANG R, et al. Physical activity, sedentary time, and risk of colorectal cancer: the Singapore Chinese Health Study[J]. Eur J Cancer Prev, 2017, 26(6):469-475.
[21] HARRISS J D, CABLE T N, GEORGE K, et al. Physical activity before and after diagnosis of colorectal cancer: disease risk, clinical outcomes, response pathways and biomarkers[J]. Sports Med, 2007, 37(11):947-960.
[22] DENLINGER C S, ENGSTROM P F. Colorectal cancer survivorship: movement matters[J]. Cancer Prev Res (Phila), 2011, 4(4):502-511.
[23] SIKANDARI H M, SIDDIQUI A, AHMAD M, et al. Effect of exercise on fatigue and depression in breast cancer women undergoing chemotherapy: a systematic review and meta-analysis[J]. Support Care Cancer, 2024, 32(8):515.
[24] GUDRUN P, BERNHARD H, BEATE M, et al. Influence of a structured exercise training on patients reported quality of life in colorectal cancer patients after adjuvant chemotherapy: a pilot study[J]. Integr Cancer Ther, 2020, 19:1534735420924072.
[25] FARDELL J E, VARDY J, SHAH J D, et al. Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity[J]. Psychopharmacology (Berl), 2012, 220(1):183-193.
[26] JAMRASI P, TAZI M, ZULKIFLI A N, et al. The potential role of exercise in mitigating fertility toxicity associated with immune checkpoint inhibitors (ICIs) in cancer patients[J]. J Physiol Sci, 2024, 74(1):57.
[27] POORNA A, KALLE M, KARIN V, et al. Home-based physical activity after treatment for esophageal cancer—a randomized controlled trial[J]. Cancer Med, 2022, 12(3):3477-3487.
[28] SIMONSEN C, THORSEN-STREIT S, SUNDBERG A, et al. Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study[J]. BJS Open, 2020, 4(5):855-864.
[29] COURNEYA K S, VARDY J L, O’CALLAGHAN C J, et al. Structured exercise after adjuvant chemotherapy for colon cancer[J]. N Engl J Med, 2025, 393(1):13-25.
[30] 中国抗癌协会肿瘤营养专业委员会, 国家市场监管重点实验室(肿瘤特医食品), 北京肿瘤学会肿瘤缓和医疗专业委员会. 中国恶性肿瘤患者运动治疗专家共识[J/CD]. 肿瘤代谢与营养电子杂志, 2022, 9(3):298-311.
[31] JIAQIU W, LIQIAN X, SHUNMEI H, et al. Low muscle mass and charlson comorbidity index are risk factors for short-term postoperative prognosis of elderly patients with gastrointestinal tumor: a cross-sectional study[J]. BMC Geriatr, 2021, 21(1):730.
[32] SCHNEIDER C M, DENNEHY C A, ROOZEBOOM M, et al. A model program: exercise intervention for cancer rehabilitation[J]. Integr Cancer Ther, 2002, 1(1):76-82.
[33] SCHMITZ K H, COURNEYA K S, MATTHEWS C, et al. American college of sports medicine roundtable on exercise guidelines for cancer survivors[J]. Med Sci Sports Exerc, 2010, 42(7):1409-1426.
[34] ROCK C L, THOMSON C A, SULLIVAN K R, et al. American cancer society nutrition and physical activity guideline for cancer survivors[J]. CA Cancer J Clin, 2022, 72(3):230-262.
[35] CAMPBELL KL, WINTERS-STONE KM, WISKEMANN J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable[J]. Med Sci Sports Exerc, 2019, 51(11):2375-2390.
[36] JING X, HONG L, MANYUEN D S, et al. Effectiveness of qigong and tai chi in the quality of life of patients with cancer: protocol for an umbrella review[J]. BMJ Open, 2022, 12(4):e057980.
[37] 张继瑶, 叶涛, 李宏玉, 等. 太极拳在疾病康复中的应用进展[J]. 中国康复, 2018, 33(5):422-424.
[38] MIURA S, NAITO T, MITSUNAGA S, et al. A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study protocol[J]. BMC Cancer, 2019, 19(1):528.
[39] 郭晨, 任弘, 曹宝山, 等. 运动处方在癌症患者群体中应用的研究进展[J]. 中国全科医学, 2020, 23(34):4394-4399.
[40] 尹国栋, 韦建勋, 韦敏克. 转移性骨肿瘤合并病理性骨折的风险评估[J]. 微创医学, 2025, 20(2):214-218.
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