Objective To explore the effect of moxibustion on early feeding tolerance and the levels of hypersensitive C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and plasma D-lactic acid in patients after radical gastrectomy for gastric cancer, and to provide evidence for the implementation of enteral nutrition after radical gastrectomy for gastric cancer. Method A total of 140 patients who underwent radical gastrectomy for gastric cancer in our hospital from April 2023 to June 2025 were selected and randomly divided into a control group (70 cases, excluding 3 cases) and an experimental group (70 cases, excluding 2 cases and dropping out 1 case) using a random number table. The control group received routine postoperative care and early enteral nutrition treatment after radical gastrectomy for gastric cancer, while the experimental group received moxibustion treatment for 30 minutes daily starting from the day of enteral nutrition in addition to the treatment of the control group. The incidence of feeding intolerance (abdominal distension and/or abdominal pain, nausea and/or vomiting, diarrhea), enteral nutrition tolerance score, enteral nutrition compliance rate, time to first anal exhaust and defecation, plasma D-lactic acid, TNF-α, and CRP levels were observed in both groups. Result The incidence of feeding intolerance and enteral nutrition tolerance score (4.35 ± 1.98) in the experimental group were lower than those in the control group, and the enteral nutrition compliance rate (90.12% ± 9.88%) was higher than that in the control group. After treatment, the levels of TNF-α (6.42 ± 1.97) pg/ml, CRP (29.98 ± 9.79) mg/L, and D-lactic acid (4.37 ± 1.27) mmol/L in both groups were lower than those before treatment, and the levels of TNF-α, CRP, and D-lactic acid in the experimental group were lower than those in the control group. The time to first exhaust (64.47 ± 19.96) h, defecation time (76.42 ± 15.14) h, and recovery time of bowel sounds (58.63 ± 12.93) h in the experimental group were shorter than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Moxibustion can improve early feeding intolerance symptoms after radical gastrectomy for gastric cancer, inhibit the release of inflammatory factors in the body, and promote the repair of intestinal mucosa.
Key words
Moxibustion /
Enteral nutrition tolerance /
Inflammatory factors /
Intestinal mucosal barrier /
Radical gastrectomy for gastric cancer
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2024,74(3):229-263.
[2] 陈杰,廉博,李孟彬,等。胃癌手术患者肠内营养治疗及肠道微生态调节的研究进展 [J/CD]. 肿瘤代谢与营养电子杂志,2020, 7 (1): 22-26.
[3] 孟云辉,黄炽彬,方丹虹。腹腔镜子宫肌瘤剔除术与传统开腹手术对患者肠道黏膜屏障功能和炎性因子水平的影响 [J]. 吉林医学,2025, 46 (10): 2402-2406.
[4] 加速康复外科围术期营养支持中国专家共识 (2019 版)[J]. 中华消化外科杂志,2019, 18 (10): 897-902.
[5] 中国抗癌协会肿瘤营养专业委员会,中华医学会肠外肠内营养学分会。胃癌患者的营养治疗专家共识 [J/CD]. 肿瘤代谢与营养电子杂志,2023, 10 (2): 208-212.
[6] 吴小丽,黄光瑞,李晓璐,等。针灸调节肠道菌群研究进展 [J]. 上海中医药大学学报,2021, 35 (2): 103-108.
[7] 中国抗癌协会胃癌专业委员会,中华医学会外科学分会胃肠外科学组。胃癌围手术期营养治疗中国专家共识 (2019 版)[J]. 中国实用外科杂志,2020, 40 (2): 145-151.
[8] 中华人民共和国国家质量监督检验检疫总局,中国国家标准化管理委员会. GB/T 21709.1-2008 针灸技术操作规范 第1部分:艾灸[S]. 北京:中国标准出版社,2008.
[9] 中国抗癌协会肿瘤营养专业委员会,中华医学会肠外肠内营养学分会。肿瘤患者肠内营养耐受不良专家共识 [J/CD]. 肿瘤代谢与营养电子杂志,2023, 10 (4): 505-508.
[10] 王姣丽,王平,曾祥娥。耐受性评估的个性化干预在急性重症胰腺炎患者肠内营养中的应用 [J]. 国际护理学杂志,2024, 43 (12): 2175-2179.
[11] 江一帆,施雁,王婧怡,等。经管饲补水对神经外科重症患者早期肠内营养喂养达标率及血糖变异性的影响 [J]. 护理学杂志,2025, 40 (8): 7-10.
[12] 缪雨希,李水芹. “脾胃为后天之本” 理论源流及发展 [J]. 四川中医,2021, 39 (2): 15-18.
[13] 《胃癌中西医结合诊疗指南》标准化项目组。胃癌中西医结合诊疗指南 (2023 年)[J]. 中国中西医结合杂志,2024, 44 (3): 261-272.
[14] 徐立雷,吴学文,朱可安,等。气街理论及其临床作用浅探 [J]. 浙江中医药大学学报,2025, 49 (5): 601-605.
[15] 罗春艳,韩韬。艾灸治疗胃肠疾病的研究进展 [J]. 中医药临床杂志,2022,34 (10): 1980-1984.
[16] 张高峰,陈洁,陆芳洁,等。增液承气汤合足三里针刺留针时长对危重症胃肠功能障碍的疗效 [J]. 中国中西医结合消化杂志,2025, 33 (12): 1199-1206.
[17] 邱煌尊,陈欣,吴佳凌,等。基于《针灸甲乙经》探讨上巨虚的临床作用 [J]. 中国民族民间医药,2025, 34 (22): 6-10.
[18] 杨锦兰,谢宇锋,蔡润钿,等。艾灸 “足三里”“梁门” 对胃热证、胃寒证模型大鼠脑皮质代谢的影响 [J]. 中医杂志,2020, 61 (11): 984-991.
[19] 陈琦,陈瑱瑶,陈宇喆,等。热敏灸对胃癌术后患者胃肠功能恢复的临床疗效观察 [J]. 广州中医药大学学报,2023, 40 (6): 1438-1442.
[20] 谢薄,吴莉莉。热敏灸对胃癌病人根治术后早期肠内营养耐受性的影响 [J]. 肠外与肠内营养,2019, 26 (2): 83-86.
[21] 南海鸥,蔡雨玲,徐鹏演,等。益气导滞方促进胃癌术后胃肠功能恢复随机对照研究 [J]. 中国中西医结合杂志,2025, 45 (1): 25-31.
[22] 郑爱东,严锡祥,崔永华,等。益生菌强化肠内营养支持对重度颅脑损伤患者肠黏膜屏障功能及炎症因子的影响 [J]. 中国医药导报,2021, 18 (1): 83-86, 91.
[23] TRIANTAFILLIDIS J K, TZOUVALA M, TRIANTAFYLLIDI E. Enteral Nutrition Supplemented with Transforming Growth Factor-β, Colostrum, Probiotics, and Other Nutritional Compounds in the Treatment of Patients with Inflammatory Bowel Disease[J]. Nutrients,2020,12(4):1048.
[24] RAINE T, VERSTOCKT B, DE CRUZ P. Immune therapies in ulcerative colitis: are we beyond anti-TNF yet?[J]. Lancet Gastroenterol Hepatol,2020,5(9):794-796.
[25] RIZO-TéLLEZ S A, SEKHERI M, FILEP J G. C-reactive protein: a target for therapy to reduce inflammation[J]. Front Immunol,2023,14:1237729.
[26] 戈扬,何培黎,施信荣。炎症性肠病患者血清免疫球蛋白及 CRP/ALB 比值与疾病活动度的关系 [J]. 中南医学科学杂志,2025, 53 (5): 883-886.
[27] 尉浩斌,张小丹,李苏宜。肠屏障功能损伤机制及其临床检测方法研究现状 [J/CD]. 肿瘤代谢与营养电子杂志,2020, 7 (4): 407-414.
[28] 莫辛,李剑钢,郭宝峰。胃癌根治术后血清微小 RNA-92a、X 型胶原 α1 链、胃泌素、胃动素水平与其预后的关系[J]. 中国临床医生杂志,2024, 52 (1): 68-71.
[29] 朱艳,张敏,赵晨.艾灸“足三里”“肾俞”对佐剂性关节炎大鼠肠道菌群的影响[J].中国针灸,2021,41(10):1119-1125.
[30] FREEDMAN S B, FLEMING D M, STEPHENS D, et al. Multicenter trial of a combination probiotic for children with gastroenteritis[J]. N Engl J Med,2018,379(21):2015-2026.
[31] ZHANG L L, ZHANG Y M, LU W T, et al. Moxibustion of Zusanli (ST36) and Shenshu (BL23) alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling[J]. J Tradit Chin Med,2024,44(2):353-361.
[32] MINALYAN A, SHAH R, GILBERT J, et al. The gastric and intestinal microbiome: role of proton pump inhibitors[J]. Curr Gastroenterol Rep,2017,19(8):42.
[33] 黄晓钰,吴丽红,王永磊。胃癌患者喂养不耐受的影响因素分析及与炎症因子的关系研究 [J/CD]. 肿瘤代谢与营养电子杂志,2024, 11 (6): 805-810.