Precision diagnosis and personalized intervention for diseases related to nutritional metabolic diseases

Zhang Jingtao; Yang Yanling

doi:10.16689/j.cnki.cn11-9349/r.2026.03.001

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2026, Vol. 13 ›› Issue (3) : 333-341. DOI: 10.16689/j.cnki.cn11-9349/r.2026.03.001

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Precision diagnosis and personalized intervention for diseases related to nutritional metabolic diseases

Zhang Jingtao, Yang Yanling

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Abstract

The human body is composed of organic and inorganic substance. Under normal conditions, it carries out synthesis and catabolism in an orderly manner to maintain health throughout the whole life. Metabolism is the main theme of life and influenced by multiple factors such as genetics, diet, sleep, exercise, environment, and diseases. Brain damage is a manifestation of various acute and chronic diseases. Intellectual impairment, learning difficulties, memory regression, psychiatric and behavioral abnormalities, epilepsy, and paralysis are often the main or early symptoms of nutritional metabolic disorders. Among acquired factors, imbalances in nutrients such as sugar, vitamins, amino acids, fatty acids, and minerals can lead to common metabolic abnormalities and inflammatory diseases. Among congenital factors, many inherited metabolic disorders usually lead to neuropsychiatric disorders, such as amino acid, organic acid, and fatty acid metabolic disorders, as well as mitochondrial and lysosomal diseases. Clues can be found through routine examinations, electrophysiology, and imaging.Metabolic studies could be performed using molecular diagnostic techniques for the analysis of blood amino acid and acylcarnitine profiles, fatty acid profiles, urine organic acid profiles, chromosomes, and genes. For potential underlying causes, internal metabolic environment can be improved by individualized dietary, nutritional, symptomatic treatment, and lifestyle intervention. Effective prevention and treatment of diseases can help patients get to normal social life.

Key words

Nutrition / Metabolism / Lifespan / Brain damage / Psychiatric disorders / Inherited metabolic disorders / Gene / Mitochondrial diseases

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Zhang Jingtao, Yang Yanling. Precision diagnosis and personalized intervention for diseases related to nutritional metabolic diseases[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2026, 13(3): 333-341 https://doi.org/10.16689/j.cnki.cn11-9349/r.2026.03.001

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