Investigation of postoperative malnutrition status in elderly patients with gastric cancer and its relationship with prognosis

Luo Ziwei; Xia Shang; Ye Zihao; Sun Mengling

doi:10.16689/j.cnki.cn11-9349/r.2026.04.009

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2026, Vol. 13 ›› Issue (4) : 512-518. DOI: 10.16689/j.cnki.cn11-9349/r.2026.04.009

Original Articles

Investigation of postoperative malnutrition status in elderly patients with gastric cancer and its relationship with prognosis

¹Luo Ziwei, ¹Xia Shang, ²Ye Zihao, ¹Sun Mengling

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Abstract

Objective To investigate the postoperative malnutrition status in elderly patients with gastric cancer, and to analyze the relationship between postoperative malnutrition status and prognosis. Method A retrospective analysis was conducted on case data of 120 elderly patients with gastric cancer admitted to the hospital from May 2019 to May 2020, and the patients were divided into group A and group B according to the postoperative nutritional status. Patients with malnutrition were included in group A, and patients with normal nutritional status were included in group B. The prognostic nutritional index (PNI) was compared between the two groups, and the risk factors affecting postoperative malnutrition in elderly patients with gastric cancer were analyzed by univariate and multivariate Logistic regression analyses, and the survival curve was drawn by Kaplan-Meier method for prognosis analysis. Result Among 120 elderly patients with gastric cancer, 85 cases had postoperative malnutrition, with the incidence rate of postoperative malnutrition of 70.83%. Univariate analysis showed that there were significant differences in tumor differentiation degree, tumor diameter, depth of tumor invasion, total cholesterol, PNI, presence or absence of adjuvant chemotherapy, anemia, lymph node metastasis and hypoproteinemia between group A and group B (P<0.05). After multivariate Logistic regression analysis, it was found that low tumor differentiation, lymph node metastasis, tumor invasion depth T3+T4a, low PNI and hypoproteinemia were independent risk factors for postoperative malnutrition in elderly patients with gastric cancer. The 5-year overall survival rate of patients in group A was 38.82% and that in group B was 54.29%. The 5-year overall survival rate in group A was significantly lower than that in group B (χ²=4.266, P=0.039). Conclusion The incidence rate of postoperative malnutrition is high in elderly patients with gastric cancer. The 5-year overall survival rate of patients with postoperative malnutrition is reduced, and the prognosis is poor. It is necessary to pay clinical attention to nutritional support therapy for high-risk population with postoperative malnutrition among elderly patients with gastric cancer.

Key words

Elderly / Patients with gastric cancer / Prognostic nutrition index / Postoperative malnutrition status / Prognosis / Overall survival rate / Hypoproteinemia

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Luo Ziwei, Xia Shang, Ye Zihao, Sun Mengling. Investigation of postoperative malnutrition status in elderly patients with gastric cancer and its relationship with prognosis[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2026, 13(4): 512-518 https://doi.org/10.16689/j.cnki.cn11-9349/r.2026.04.009

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