The correlation between intestinal microecology and the efficacy of chemotherapy

ZIWAREGULI Nur; FANG Ruo-xin; LIAO Zheng-kai

doi:10.16689/j.cnki.cn11－9349/r.2019.02.002

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2019, Vol. 6 ›› Issue (2) : 161-166. DOI: 10.16689/j.cnki.cn11－9349/r.2019.02.002

The correlation between intestinal microecology and the efficacy of chemotherapy

ZIWAREGULI Nur, FANG Ruo-xin，LIAO Zheng-kai

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Abstract

There is a symbiotic or antagonistic relationship between human intestinal flora, and a unique intestinal microecosystem is formed. After a long period of co-evolution, intestinal flora and human body have formed a close symbiotic relationship, and participate in many important physiological activities of the human body. Therefore, maintaining the balance of intestinal flora is essential to human health. The formation of human intestinal flora structure depends on many factors, such as diet, sex, mode of delivery, host genetic characteristics, host lifestyle, disease occurrence and antibiotic exposure. Escherichia coli, bifidobacteria, Lactobacillus and Proteus are the main intestinal flora in healthy people. Under normal physiological conditions, these bacteria maintain a dynamic balance of species and quantity. They can not only protect intestinal epithelial cells, but also participate in the physiological processes of immunity, nutrition, biological antagonism, anti-aging and anti-cancer in the life activities of the host. Intestinal flora can inhibit the occurrence and development of tumors and regulate inflammation by activating anti-tumor cytokines, regulating intestinal microenvironment and maintaining genomic stability. Moreover, the complete intestinal flora is also conducive to the development of anti-cancer drugs. Intestinal flora can affect the efficacy and toxicity of chemotherapy through flora translocation, immune regulation, metabolism, enzymatic degradation, diversity reduction and microecological changes. At the same time, chemotherapy can significantly affect the composition of intestinal flora, destroy the balance of intestinal microecology, and aggravate the discomfort of patients. More and more evidences show that intestinal bacteria can affect the efficacy or toxicity of chemotherapy, and that intestinal microecology may improve the efficacy and reduce toxicity of chemotherapy. This article reviews the relationship between intestinal flora and the efficacy and side effects of chemotherapy.

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Gastrointestinal microbiome / Cancer therapy / Chemotherapy

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ZIWAREGULI Nur, FANG Ruo-xin，LIAO Zheng-kai. The correlation between intestinal microecology and the efficacy of chemotherapy[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(2): 161-166 https://doi.org/10.16689/j.cnki.cn11－9349/r.2019.02.002

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