Expert consensus on clinical use of compound amino acid injection

doi:10.16689/j.cnki.cn11－9349/r.2019.02.006

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Electronic Journal of Metabolism and Nutrition of Cancer ›› 2019, Vol. 6 ›› Issue (2) : 183-189. DOI: 10.16689/j.cnki.cn11－9349/r.2019.02.006

1GAO Chun， 1LI Meng， 2WEI Jun-min， 3LI Yu-zhen， 4TIAN Wei-jun， 5JIANG Hai-ping， 6SHEN Wei， 7XU Ai-guo， 8YU Zhen， 9CHEN Dong-sheng， 10CHEN Lian-zhen， 11GUAN Wen-xian， 12JIANG Hua， 13LI Da-kui， 13MEI Dan， 14YU Ji-ren， 7ZHAO Chun-lin， 15FAN Wei， 16HU Song， 17KANG Yan， 13KANG Wei-ming， 18LV Chuan-zhu， 1LIU Dong， 19LIU Hui， 9LV Yong-ning， 20MENG Xiang-ling， 21SONG Jin-chun， 12SUN Ming-wei， 22TANG Qing-ya， 23WANG Lie， 24WANG Jing-jie， 25WU Dong-fang， 26XU Yuan， 27XU Hua， 22YAN Wei-hui， 13YAN Xue-lian， 12ZENG Jun， 28ZHANG Pian-hong， 1GONG Jian-ping，29GUO Zeng-qing， 1HU Jun-bo， 30MENG Qing-hua， 31LI Zeng-ning，32QIAN Su-yun，33QIN Bao-li， 34SHEN Sheng-rong，35TIAN Zi-bin， 36XU Hong-xia， 1YAO Ying，37YU Le-cheng， 38SHI Han-ping； Chinese Society for Parenteral and Enteral Nutrition， Chinese Society of Nutritional Oncology

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1Tongji Hospital， Tongji Medical College， HuaZhong University of Science and Technology， Wuhan 430030， Hubei， China；2Beijing Hospital/National Center of Gerontology， Beijing 100730， China；3Peking University People’s Hospital， Beijing 100044， China；4General Hospital of Tianjin Medical University， Tianjin 300052， China；5The First Affiliated Hospital of Jinan University， Guangzhou 510630， Guangdong， China；6The Second Affiliated Hospital of Nanchang University， Nanchang 330006， Jiangxi， China；7The First Affiliated Hospital of Zhengzhou University， Zhengzhou 450052， Henan， China；8Tenth People’s Hospital of Tongji University， Shanghai 200072， China；9Union Hospital， Tongji Medical College， Huazhong University of Science and Technology， Wuhan 430022， Hubei， China；10Chinese Academy of Medical Sciences Cancer Hospital， Beijing 100029， China；11Nanjing Drum Tower Hospital， the Affiliated Hospital of Nanjing University Medical School， Nanjing 210008， Jiangsu， China；12Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital， Chengdu 610072， Sichuan， China；13Peking Union Medical College Hospital， Beijing 100730， China；14The First Affiliated Hospital， Zhejiang University School of Medicine， Hangzhou 310003， Zhejiang， China；15Guizhou Provincial People’s Hospital， Guiyang 550002， Guizhou， China；16Wuhan No. 1 Hospital， Wuhan 430022， Hubei， China；17West China Hospital of Sichuan University， Chengdu 610041， Hubei， China；18Hainan Medical University， Haikou 571199， Hainan， China；19General Hospital of Central War Zone of the Chinese People’s Liberation Army， Wuhan 430070， Hubei， China；20The First Affiliated Hospital of Anhui Medical University， Hefei 230022， Anhui， China；21Renmin Hospital of Wuhan University， Wuhan 430060， Hubei， China；22Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine， Shanghai 200092， China；23the PLA’s 900 Hospital of the Joint Logistics Team， Fuzhou 350025， Fujian， China；24Tangdu Hospital， Fourth Military Medical University， Xi’an 710038， Shanxi， China；25Zhongnan Hospital of Wuhan University， Wuhan 430071， Hubei， China；26Beijing Tsinghua Changgung Hospital， Beijing 102218， China；27Wuhan Children’s Hospital， Wuhan 430015， Hubei， China；28Second Affiliated Hospital， Zhejiang University School of Medicine， Hangzhou 310009， Zhejiang， China； 29Fujian Province Cancer Hospital， Fujian Medical University Affiliated Cancer Hospital，Fuzhou 350014， Fujian， China；30Beijing Youan Hospital， Capital Medical University， Beijing 100069， China；31The First Hospital of Hebei Medical University， Shijiazhuang 050031， Hebei， China；32Beijing Children’s Hospital， Capital Medical University， Beijing 100045， China； 33Liaoning Tumor Hospital，Shenyang 110042， Liaoning， China；34School of Public Health， Zhejiang University， Hangzhou 310058， Zhejiang， China；35The Affiliated Hospital of Qingdao University， Qingdao 266000， Shandong， China；36Daping Hospital， Army Medical University， Chongqing 400042， China；37The General Hospital of Eastern Theater Commander， the Bayi Hospital Affiliated to Nanjing University of Chinese Medicine， Nanjing 210002， Jiangsu， China；38Beijing Shijitan Hospital， Capital Medical University， Beijing 100038， China

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Abstract

Compound amino acid injection， as the source of nitrogen in parenteral nutrition， is administrated to patients with compromised gastrointestinal function or whose nutritional needs cannot be satisfied via the GI tract. Therefore， compound amino acid injection is crucial in nutrition therapies. However， a consensus does not exist in China regarding its indications， formulations， dosages， and the timing of administration. Experts in the field are recruited by the Chinese Society for Parenteral and Enteral Nutrition (CSPEN) and the Chinese Society of Nutritional Oncology (CSNO) to formulate a consensus paper. The current paper aims to provide standardized guidance for clinical use of compound amino acid injection. The consensus paper is a composite of systematically reviewing pertinent literature， Chinese clinical practice， and multiple sessions of debate， discussion， and composition， with reference to guidelines from American Society for Parenteral and Enteral Nutrition (ASPEN)， European Society for Clinical Nutrition and Metabolism (ESPEN)， CSPEN， and CSNO. This consensus presents 10 recommendations for protein needs and appropriate compound amino acid injection formulas to serve varied patients.

Key words

Compound amino acid injection / Parenteral nutrition / Protein / Nutrition therapy / Expert consensus

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GAO Chun， LI Meng， WEI Jun-min， LI Yu-zhen， TIAN Wei-jun， JIANG Hai-ping， SHEN Wei， XU Ai-guo， YU Zhen， CHEN Dong-sheng， CHEN Lian-zhen， GUAN Wen-xian， JIANG Hua， LI Da-kui， MEI Dan， YU Ji-ren， ZHAO C. Expert consensus on clinical use of compound amino acid injection[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(2): 183-189 https://doi.org/10.16689/j.cnki.cn11－9349/r.2019.02.006

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