Abstract：Objective To evaluate the efficiency of early enteral nutritional support in patients underwent laryngectomy. Methods We retrospectively reviewed and analyzed 329 larynx cancer patients underwent total or partial laryngectomy from November 2003 to July 2013 in Daping Hospital. Of these patients, 278 (EN group) were given enteral nutrition with commercial formulations within 24 hours after the surgery through the nasogastric tube, 51 patients (Convenience diet group， CD group) rejected the enteral nutrition treatment and were on homogenated diet. We compared the rate of fistula formation, post-surgical infection rate, average length of hospitalization, and other clinical indicators between the two groups. Results 13 patients (13/278, 4.68%) in the EN group, and 6 patients (6/51, 11.76%) in the CD group had fistula formation. The difference is found statistically significant (P<0.046). The differences of post-surgical infection rate, average length of hospitalization and other clinical indicators between the two groups are not statistically significant. Conclusions The risk of fistula formation may be shortened in patients underwent laryngectomy by giving early enteral nutrition.