Abstract:Objective To summarize the late advance of ubiquitin-proteasome system in cancer cachexia and conclude its regulatory mechanisms and possible targets of cachexia therapy. Methods Related articles were obtained through comprehensive search in the database Pubmed with the keywords“cancer, cachexia, ubiquitin, proteasome”. Results Dysregulated cytokines resulting from cancer bearing promote muscle protein degradation via ubiquitin-proteasome system, which benefits for initiation and progression of cancer cachexia. Conclusions The ubiquitin-proteasome system may be a novel target of cachexia therapy. Elucidation of how ubiquitinated proteins are specifically recognized by proteasome and identification of its upstream regulatory factors would contribute to improvement of clinical therapy in cachexia.