Abstract: Objective To summarize the function of lipid-mobilizing factor/Zn-α2-glycoprotein in cancer cachexia. Methods The related literatures were reviewed. Results LMF/ZAG can stimulate fat mobilization and triglyceride hydrolysis in adipose tissue directly via GTP dependent cAMP pathway, and accelerate the consumption and oxidation of white adipose tissue, thus playing a vital role in lipid metabolism and energy balance in cancer cachexia. Meanwhile the changes of lipid metabolism induced by LMF/ZAG and their metabolic products have an important influence on the whole body protein and glucose metabolism. Conclusions LMF/ZAG acts as the key factor of fat consumption and plays an important role in the whole material metabolic disorders in cancer cachexia.