Objective To investigate the clinical values of erythropoietin (EPO) in the patients with digestive tracts cancer in Guangdong General hospital. Methods 226 cases of digestive tracts cancer were analyzed, retrospectively. Results There are signifcant differences of EPO between the groups with and without anemia in patients with digestive tracts cancers, while these patients with different degrees of anemia showed signifcant differences in levels of EPO. Conclusions The EPO in patients with IV stage and metastasis usually had higher levels than that of earlier stage and without metastasis.