Objective To investigate the perioperative management of patients over 80 years old with colorectal cancer. Methods From June 2006 to June 2012, clinical data of 41 patients over 80 years old with colorectal cancer was analyzed retrospectively. Results Of all patients, 4 patients underwent emergency operation, 37 patients accepted limited operation. 31 patients underwent radical resection and 9 patients underwent palliative resection, transverse colostomy was performed in 1 patient. 15 patients had complications, 39 patients were healing well completely except that 2 patients died after operation. Conclusions For colorectal cancer patients, old age should not be surgical contraindication. Short-term outcomes will be achieved while paying attention to organ functions especially the cardiorespiratory function and nutritional status controlling surgical trauma and surgical time.