Objective To investigate the clinical effect of the nutrition intervention of different vitamins and minerals proportion during the perioperative period of total gastrectomy. Methods 21 cases total gastrectomy for gastric cancer patients were divided into three groups and all patients started early enteral nutrition support on the frst days after operation. Group A,B,C were respectively treated with high, middle and low vitamin and minerals proportion nutritional support, and the body weight, hemoglobin, prealbumin, plasma protein, liver and kidney function, blood glucose, electrolytes, exhaust time before and after nutrition support were recorded. Results 21 cases with no death , no serious complications, liver and kidney function had no change during the study. Nutritional index of group A was superior to that of groups B, C and have no statistical difference with the preoperative nutritional level. Conclusions Effect of a few mineral with a large number of vitamins used in nutrition support can achieve better, and suitable for nursing and treatment in operation period of total gastrectomy