Objective? ?To evaluate the effectiveness and nursing method of pre-operation oral bile in patient of hilar cholangiocarcinoma. Methods 80 patients’ clincal datum of hilar cholangiocarcinoma in Biliary Tract Surgery Dept 1 from August 2012 to January 2014 were collected, all of the patients accepted percutaneous transhepatic choledochus drainage (PTCD) before abdominal operation. According to exclusion criteria, 7 patients was not included in the analysis. According to oral bile or not, those patients were divided into two groups, the treatment group (PTCD+oral bile, n=39) and the control group (PTCD only, n=34). 5 days after PTCD, oral bile began in the treatment group. The serum test (liver function and electrolytes) was performed on day 5, day 8 and day 12 after PTCD. At the same time point, the bile ?ux, the transfusion volume, and the quantity of potassium supplement in 24 hours were recorded. The patients’ symptoms of anorexia or not were also recorded. χ2 test, t test and repeated measures were used to do the statistical analysis. Results After oral bile: (1)Appetite improvement rate, the treatment group increased signifcantly than the control group day 8 (P=0.009) and day 12 (P=0.001) after PTCD. In treatment group, 10 patients (10/39) had mild stomach discomfort, 3 patients (3/39) had mild distention. After psychological care and oral method of adjusting, the 13 patients tolerated the oral bile. (2) The serum total protein (P=0.017) and prealbumin (P=0.019) , the treatment group also increased signifcantly than the control group, while, the decrease rate of serum total bilirubin had no signifcant difference (P=0.989). (3)The transfusion volume (P=0.017) and supplement of potassium (P=0.011) the treatment group decreased signifcantly than the control group. Conclusions Compared with the only PTCD, PTCD combined with oral bile, was a kind of better method for pre-operation preparation in patient of hilar cholangiocarcinoma. PTCD combined with oral bile not only reduced the amount of transfusion and the supplement of potassium, but also signifcantly improved the nutritional situation of the patients.