Abstract: Objective To summarize research outcomes about vitamin C selectively kills KRAS, BRAF mutant colorectal cancer cells in cancer treatment, analysis and generalize the physiological mechanism. Methods Related articles were retrieved by searching the PubMed and CNKI database with the key words “vitamin C” and “colorectal cancer”. Results Combine the metabolic characteristics of tumor and the influence by ROS, vitamin C can be transport into cancer cells accompany with high glycolysis level resulting from KRAS, BRAF mutant cell. Due to unbalanced oxidation-reduction state in cells, cancer cells were killed by energy supply blocked. Conclusions High doses vitamin C via intravenous administration can restrain tumor growth in KRAS and BRAF mutant mice, these finding may provide a mechanistic rationale for further clinical trials.