A phenome is the whole phenotypes expressed by an organism. Phenomics is a systematic study about the whole phenomes of organisms or cells in different environments, especially concern the laws of changing of physical and chemical character. In 1996, Steven A. Garan, director of the aging research centre (ARC), proposed the concept of phenomics at a guest lecture at the University of Waterloo. In 2005, Christophe published a significant article, in which he elaborated the technical facility by crop design company in Belgium, so called Trait Mill, can be used to analyze large-scale plant phenotypes in the whole growth period automatically on a large scale. In 2014, Zoltan Takats, a professor in British imperial college, reported the iKnife in the study of the tumor phenome and metabolomics, which is a new technology for surgeons identify tumor. Nuclear magnetic resonace and mass spectrometry is the most common method in clinical phenomics. In addition, the ultraviolet absorption, high performance liquid chromatography high performance liquid chromatography, gas chromatography technical means such as fluorescent scattering also gradually be introduced in this field of research. After decades of development, phenomics have got many significant breakthroughs, which seem to be promising for wide clinical application. This paper is to summarize the concept, development and clinical application of phenomics.